Synthesis of 4-amino-7-methylthieno[3,2-d]pyrimidin-6-yl}benzene-1-sulfonamide

[PatrickThomson]

This compound is currently being synthesised as per issue 103

[PatrickThomson]

@alintheopen, can you tag this with the new tag? I don't think I've got the authority over tags. Ta!

[PatrickThomson]

Also, the "close and comment" and "comment" buttons are right next to each other.

[PatrickThomson]

First step here.

[mattodd]

Really? That's odd. Must fix.
On Nov 28, 2013 1:18 AM, "PatrickThomson" notifications@github.com wrote:

@alintheopen https://github.com/alintheopen, can you tag this with the
new tag? I don't think I've got the authority over tags. Ta!

—
Reply to this email directly or view it on GitHubhttps://github.com//issues/118#issuecomment-29387049
.

[PatrickThomson]

To complete this synthesis it would be helpful to get a sample of the following molecule. If it cannot arrive in the UK by March 27th, for whatever reason, I will make it instead. @alintheopen ?

[mattodd]

Hi @PatrickThomson - to clarify, is this molecule not being pursued, based on what you say in #161 ? If so, should we close this issue? This molecule would ideally be put into the Series 3 wiki along with a link to this Issue to maintain the connection.

[PatrickThomson]

I'm doing both of them - methyl on the thiophene as per here, and methyl on the benzenesulfonamide as per #161

I've sent got 3-bromobenzenesulfonamide to make the shown precursor if necessary.

[alintheopen]

Hi Patrick, If you've got the precursor then yes I'd go ahead with the synthesis as its a quick overnight reaction and we haven't got very much material left so I'd have to make it and then send it.

[PatrickThomson]

I've got all the precursors here, that's good to know, cheers @alintheopen !

[PatrickThomson]

Closing this to focus on the other of the two "twisted methyl" compounds, #161

[mattodd]

OK - just to note that we ought to try to be mindful of orphaning links/work when we close issues. I think this is not a problem here since you referred to 161 in the above, which keeps it alive. I installed a note to this Issue/compound on the Series 3 wiki so that when that page is spruced, we can maintain a note that says this compound is a decent one to pursue, and was looked at, but that it has not been pursued actively here.