[PA165986114] Bad GPML for Tacrolimus/Cyclosporine Pathway, Pharmacokinetics

[pharmgen]

Latest GPML for pathwayPA165986114 is obsolete.
Use this instead: PA165986114-new.gpml

Note that even the updated GPML has errors that must be fixed:

• 'cyclosporine am9' [id:a141d]: Evidence should only be provided on interactions.
• 'cyclosporine am1' [id:ac040]: Evidence should only be provided on interactions.
• 'cyclosporine am4n' [id:be41b]: Evidence should only be provided on interactions.
• 'Elimination (Bile;Urine)' [id:e4b34]: Missing PharmGKB Accession ID.
• 'Elimination (Bile;Urine)' [id:e4b34]: BlackBox should be converted to Phenotype or Process.
• '13-o-demethyl-tacrolimus' [id:f225a]: Evidence should only be provided on interactions.
• 'Elimination (Feces)' [id:f2ac1]: Missing PharmGKB Accession ID.
• 'Elimination (Feces)' [id:f2ac1]: BlackBox should be converted to Phenotype or Process.
• '31-o-demethyl-tacrolimus' [id:f8182]: Evidence should only be provided on interactions.
• '13-o-demethyl-tacrolimus' [id:c5dcd]: Evidence should only be provided on interactions.
• '31-o-demethyl-tacrolimus' [id:beb72]: Evidence should only be provided on interactions.
• 'cyclosporine am4n' [id:e6df6]: Evidence should only be provided on interactions.
• 'cyclosporine am9' [id:b677f]: Evidence should only be provided on interactions.
• 'cyclosporine am1' [id:a2ecf]: Evidence should only be provided on interactions.
• Biochemical Reaction line [id:a586e] (from 'tacrolimus' [id:d0cff] to '13-o-demethyl-tacrolimus' [id:f225a]): Missing evidence.
• Biochemical Reaction line [id:b7353] (from 'cyclosporine' [id:bd9a4] to 'cyclosporine am4n' [id:e6df6]): Missing evidence.
• Transport line [id:ccff2] (from 'tacrolimus' [id:d0cff] to 'tacrolimus' [id:adb09]): Missing evidence.
• Transport line [id:dc618] (from 'cyclosporine' [id:be5ec] to 'cyclosporine' [id:bd9a4]): Missing evidence.
• Biochemical Reaction line [id:f4897] (from 'cyclosporine' [id:be5ec] to 'cyclosporine am4n' [id:be41b]): Missing evidence.
• Biochemical Reaction line [id:id253c0fe3] (from 'cyclosporine' [id:be5ec] to 'cyclosporine am1' [id:ac040]): Missing evidence.
• Activation line [id:id2ae5052d] (from 'cyclosporine am4n' [id:e6df6] to 'Elimination (Bile;Urine)' [id:e4b34]): Missing evidence.
• Biochemical Reaction line [id:id3072e97f] (from 'cyclosporine' [id:bd9a4] to 'cyclosporine am1' [id:a2ecf]): Missing evidence.
• Biochemical Reaction line [id:id46baa598] (from 'cyclosporine' [id:bd9a4] to 'cyclosporine am9' [id:b677f]): Missing evidence.
• Biochemical Reaction line [id:id67f286ec] (from 'tacrolimus' [id:adb09] to '31-o-demethyl-tacrolimus' [id:beb72]): Missing evidence.
• Activation line [id:id74b13449] (from 'cyclosporine am1' [id:ac040] to 'Elimination (Feces)' [id:f2ac1]): Missing evidence.
• Biochemical Reaction line [id:id785cbdfd] (from 'tacrolimus' [id:d0cff] to '31-o-demethyl-tacrolimus' [id:f8182]): Missing evidence.
• Activation line [id:ida49ecd0e] (from '13-o-demethyl-tacrolimus' [id:c5dcd] to 'Elimination (Bile;Urine)' [id:e4b34]): Missing evidence.
• Activation line [id:idb1e8cc41] (from 'cyclosporine am1' [id:a2ecf] to 'Elimination (Bile;Urine)' [id:e4b34]): Missing evidence.
• Activation line [id:idb34a00a5] (from '31-o-demethyl-tacrolimus' [id:f8182] to 'Elimination (Feces)' [id:f2ac1]): Missing evidence.
• Activation line [id:idb8726512] (from 'cyclosporine am9' [id:a141d] to 'Elimination (Feces)' [id:f2ac1]): Missing evidence.
• Activation line [id:idca2b748] (from 'cyclosporine am9' [id:b677f] to 'Elimination (Bile;Urine)' [id:e4b34]): Missing evidence.
• Biochemical Reaction line [id:idcaae0829] (from 'cyclosporine' [id:be5ec] to 'cyclosporine am9' [id:a141d]): Missing evidence.
• Activation line [id:idcc8667ad] (from 'cyclosporine am4n' [id:be41b] to 'Elimination (Feces)' [id:f2ac1]): Missing evidence.
• Activation line [id:idee0b96d6] (from '13-o-demethyl-tacrolimus' [id:f225a] to 'Elimination (Feces)' [id:f2ac1]): Missing evidence.
• Activation line [id:idf295b13d] (from '31-o-demethyl-tacrolimus' [id:beb72] to 'Elimination (Bile;Urine)' [id:e4b34]): Missing evidence.
• Biochemical Reaction line [id:a0201] (from 'tacrolimus' [id:adb09] to '13-o-demethyl-tacrolimus' [id:c5dcd]): Missing evidence.