-
Notifications
You must be signed in to change notification settings - Fork 4
Commit
This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository.
adding dummy article page for Pan et al article now updated on figsha…
…re staging
- Loading branch information
Showing
1 changed file
with
23 additions
and
0 deletions.
There are no files selected for viewing
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,23 @@ | ||
Slug: 10.5072/FK2.stagefigshare.c.2814593 | ||
DOI: 10.5072/FK2.stagefigshare.c.2814593 | ||
Title: The cardiac Na+/K+ ATPase: An updated, thermodynamically consistent model. | ||
Date: 2020-05-21 | ||
SubmissionDate: 2017-04-15 | ||
PublishDate: 2020-05-06 | ||
LastPublishDate: 2020-05-06 | ||
Kind: original | ||
PubAuthors: Pan, M. | ||
Blanco, P. J. | ||
Müller, L. O. | ||
Hunter, P. J. | ||
Safaei, S. | ||
PubAuthorsORCID: 0000-0001-6492-2619 | ||
0000-0003-3527-619X | ||
0000-0003-1933-8995 | ||
0000-0001-9665-4145 | ||
0000-0001-5734-243X | ||
PrimaryPaperName: Bond Graph Model of Cerebral Circulation: Toward Clinically Feasible Systemic Blood Flow Simulations. 2018, S. Safaei, P.J. Blanco, L.O. Müller, L.R. Hellevik, P.J. Hunter | ||
PrimaryPaperURL: https://doi.org/10.1152/ajpheart.00771.2007 | ||
FulltextURL: https://physiome.figsh.com/collections/Pan_et_al_2020_The_cardiac_Na_K_ATPase_An_updated_thermodynamically_consistent_model/2814593 | ||
ArchiveURL: https://physiome.figsh.com/collections/Pan_et_al_2020_The_cardiac_Na_K_ATPase_An_updated_thermodynamically_consistent_model/2814593 | ||
Abstract: The Na+/K+ ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over successive heart beats. Terkildsen et al. (2007) developed a model of the ventricular myocyte Na+/K+ ATPase to study extracellular potassium accumulation during ischaemia, demonstrating the ability to recapitulate a wide range of experimental data, but unfortunately there was no archived code associated with the original manuscript. Here we detail an updated version of the model and provide CellML and MATLAB code to ensure reproducibility and reusability. We note some errors within the original formulation which have been corrected to ensure that the model is thermodynamically consistent, and although this required some reparameterisation, the resulting model still provides a good fit to experimental measurements that demonstrate the dependence of Na+/K+ ATPase pumping rate upon membrane voltage and metabolite concentrations. To demonstrate thermodynamic consistency we also developed a bond graph version of the model. We hope that these models will be useful for community efforts to assemble a whole-cell cardiomyocyte model which facilitates the investigation of cellular energetics. |