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*/__pycache__
pretrained_weights/isecret.pt
pretrained_weights/led.bin
pretrained_weights/pcenet.pth
201 changes: 201 additions & 0 deletions LICENSE
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# Learning Enhancement From Degradation: A Diffusion Model For Fundus Image Enhancement

The official implementation of the paper ``Learning Enhancement From Degradation: A Diffusion Model For Fundus Image Enhancement``. The related paper link will be updated soon.


![image info](./docs/led.gif)

## Highlights
- ### Continuous and reliable enhancement
![image info](./docs/Continuous.png)

- ### Flexable and ffectively integrated into any SOTA
![image info](./docs/OC.png)

![image info](./docs/vessels.png)

- ### Robust for OOD low-quality images
![image info](./docs/jpeg_loss.png)

![image info](./docs/mf_loss.png)

- ### SOTA performance
![image info](./docs/performance.png)

Start LED with few lines

```python
from led.pipelines.led_pipeline import LEDPipeline
led = LEDPipeline()
led.cuda()
led_enhancement = led('./doc/example.jpeg')[0]
```

Furthermore, you can combine LED with any existing SOTA methods as external backend. Current supported backends include:
- I-SECRET
- PCE-Net

Try
```python
led = LEDPipeline(backend='I-SECRET', num_cond_steps=200)
```

For more details, please read exmaple.ipynb.

## Catalog
- [ ] Training guidance
- [ ] Support for ArcNet and SCRNet
- [ ] Add related codes for data-driven degradation
- [x] Inference pipeline

## Train
For training your own LED, you need to update few lines in configs/train_led.yaml
```yaml
train_good_image_dir: # update to training hq images directrory
train_bad_image_dir: # update to training lq images directrory
train_degraded_image_dir: # update to training degraded images directrory
val_good_image_dir: # update to validation hq images directrory
val_bad_image_dir: # update to validation lq images directrory
```
Please note that ``train_degraded_image_dir`` should contain degraded high-qualty images by any data-driven methods. We will inculde related codes in our future workspace. However, you can consider using some existing repos instead, like [CUT](https://github.com/taesungp/contrastive-unpaired-translation) or [CycleGAN](https://github.com/junyanz/pytorch-CycleGAN-and-pix2pix).

To train LED, simply run
```bash
accelerate launch --mixed_precision fp16 --gpu_ids 0 --num_processes 1 script/train.py
```
More GPUs will take significant performance improvement.


## Acknowledgement
Thanks for [PCENet](https://github.com/HeverLaw/PCENet-Image-Enhancement), [ArcNet](https://github.com/liamheng/Annotation-free-Fundus-Image-Enhancement) and [SCRNet](https://github.com/liamheng/Annotation-free-Fundus-Image-Enhancement) for sharing their powerful pre-trained weights! Thansk for [diffusers](https://github.com/huggingface/diffusers) for sharing codes.

## Citation

If this work is helpful for your research, please consider citing the following BibTeX entry.

```
Will be updated
```
## License
This repository is released under the Apache 2.0 license as found in the [LICENSE](LICENSE) file.
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seed: 42

# data
data:
train_good_image_dir: # high quality images
train_bad_image_dir: # low quality images
train_degraded_image_dir: # degraded images
val_good_image_dir: # high quality images
val_bad_image_dir: # low quality images
image_size: 512

# model
model:
sample_size: ${data.image_size}
in_channels: 6
out_channels: 3
center_input_sample: false
time_embedding_type: positional
freq_shift: 0
flip_sin_to_cos: true
down_block_types:
- DownBlock2D
- DownBlock2D
- DownBlock2D
- DownBlock2D
- AttnDownBlock2D
- DownBlock2D
up_block_types:
- UpBlock2D
- AttnUpBlock2D
- UpBlock2D
- UpBlock2D
- UpBlock2D
- UpBlock2D
block_out_channels:
- 128
- 128
- 256
- 256
- 512
- 512
layers_per_block: 2
mid_block_scale_factor: 1
downsample_padding: 1
act_fn: silu
attention_head_dim: 8
norm_num_groups: 32
norm_eps: 1.0e-05
resnet_time_scale_shift: default
add_attention: true


# training
train:
lr: 1e-5
lr_warmup_steps: 100
adam_beta1: 0.95
adam_beta2: 0.999
adam_eps: 1e-08
weight_decay: 1e-6
gradient_accumulation_steps: 1
num_epochs: 150
ema_max_decay: 0.9999
checkpointing_steps_total_limit: None
ema_inv_gamma: 1.0
ema_power: 0.75
checkpointing_steps: 1000
save_images_epochs: 5
adv_start_epoch: 5
save_model_epochs: 50

diffusion:
num_train_steps: 1000
prediction_type: epsilon
num_inference_steps: 50
beta_schedule: linear
num_cond_steps: 800

output_dir: './logs/LED'
mixed_precision: 'fp16'
gpus: 0,1,2,3,6,7
num_worker: 8
train_batch_size: 3
eval_batch_size: 16
test_batch_size: 16

optimizer_name: adamw
model_name: unet
lr_scheduler_name: cosine
use_ema: true
logger_name: tensorboard
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from led.pipelines.led_pipeline import LEDPipeline
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