Targeted assemble Cas1 from metagenome bypassing annotating Cas proteins from de-novo assemblies
We constructed eight Cas1 Hidden Markov models (HMMs) to cover Cas1 diversity and assembled them directly from metagenomes by a targeted-gene assembler, Xander (Wang, Q., et al., 2015).
The eight Xander packages including the HMMs were uploaded here.
Reference: Wang Q, Fish JA, Gilman M, Sun Y, Brown CT, Tiedje JM, Cole JR. Xander: employing a novel method for efficient gene-targeted metagenomic assembly. Microbiome. 2015 Dec;3(1):32