This repository holds the scripts, RMarkdown files, and their html rendering from Nikhil Milind's summer project 2018-2019 in the Carter lab. The full project folder is in '/sdata/carter-lab/carter/AMPAD/AMPAD_Submodules/` on tier1. Results from this project are available on Synapse.
Co-expression modules were generated by Logsdon et al. (2019) for transcriptomic data from the AMP-AD cohorts (10.7303/syn11932957.1). In this project, we generate submodules by pruning genes and dividing the broad modules into pathway-specific gene sets. We also generated quantitative traits for single-variant association mapping.
More information about where to find specific analyses or results can be found in Summer2019Report.html and Summer2018Report.html.
This project is now published in:
Milind N, Preuss C, Haber A, Ananda G, Mukherjee S, John C, et al. (2020) Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology. PLoS Genet 16(6): e1008775. https://doi.org/10.1371/journal.pgen.1008775
Scripts are written in either R(3.5.3) or Python(3.7.3). Other important softwares used include:
Inkscape(0.92.2)Cytoscape(3.7.1)RStudio(1.2.1335)PLINK(1.07)EMMAX(2012-02-05 from http://csg.sph.umich.edu//kang/emmax/download/index.html)