Cottrazm

Cottrazm (Construct Tumor Transition Zone (Boundary) Microenvironment based on spatial transcriptomics) aims to construct the microenvironment of tumor boundary based on spatial transcriptomics, single-cell transcriptomics and HE-stained histological images. It consists of three core functions: determining the tumor boundary (Cottrazm-BoundaryDefine), deconvoluting spatial transcriptomics (Cottrazm-SpatialDecon), and reconstructing a spatial gene expression matrix for sub-spots (Cottrazm-SpatialRecon).