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CaMKIIs.xml
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CaMKIIs.xml
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<?xml version="1.0" ?>
<VectorField Name="CaMKIIs">
<Constant Name="s" Description="small, non-zero number" Latex="0 \gt \eps \ll 1" Value="1e-5"/>
<Parameter Name="kf__CaM__Ca" Description="independent parameter" DefaultValue="0.0021524"/>
<Parameter Name="kf__CaM_Ca1__Ca" Description="independent parameter" DefaultValue="0.0088968"/>
<Parameter Name="kf__CaM_Ca2__Ca" Description="independent parameter" DefaultValue="0.028311"/>
<Parameter Name="kf__CaM_Ca3__Ca" Description="independent parameter" DefaultValue="0.041046"/>
<Parameter Name="kf__CaM__PP2B" Description="independent parameter" DefaultValue="0.046"/>
<Parameter Name="kf__CaM_Ca1__PP2B" Description="independent parameter" DefaultValue="0.046"/>
<Parameter Name="kf__CaM_Ca2__PP2B" Description="independent parameter" DefaultValue="0.046"/>
<Parameter Name="kf__CaM_Ca3__PP2B" Description="independent parameter" DefaultValue="0.046"/>
<Parameter Name="kf__CaM_Ca4__PP2B" Description="independent parameter" DefaultValue="0.046"/>
<Parameter Name="kf__PP2B_CaM__Ca" Description="independent parameter" DefaultValue="0.0016667"/>
<Parameter Name="kf__PP2B_CaM_Ca1__Ca" Description="independent parameter" DefaultValue="0.016667"/>
<Parameter Name="kf__PP2B_CaM_Ca2__Ca" Description="independent parameter" DefaultValue="0.008125"/>
<Parameter Name="kf__PP2B_CaM_Ca3__Ca" Description="independent parameter" DefaultValue="0.092857"/>
<Parameter Name="KD__CaM_Ca3__Ca" Description="independent parameter" DefaultValue="15836"/>
<Parameter Name="KD__CaM_Ca2__Ca" Description="independent parameter" DefaultValue="22959"/>
<Parameter Name="KD__CaM_Ca1__Ca" Description="independent parameter" DefaultValue="1124"/>
<Parameter Name="KD__CaM__Ca" Description="independent parameter" DefaultValue="4646"/>
<Parameter Name="KD__CaM_Ca4__PP2B" Description="independent parameter" DefaultValue="0.028"/>
<Parameter Name="KD__PP2B_CaM_Ca3__Ca" Description="independent parameter" DefaultValue="70"/>
<Parameter Name="KD__PP2B_CaM_Ca2__Ca" Description="independent parameter" DefaultValue="800"/>
<Parameter Name="KD__PP2B_CaM_Ca1__Ca" Description="independent parameter" DefaultValue="60"/>
<Parameter Name="KD__PP2B_CaM__Ca" Description="independent parameter" DefaultValue="600"/>
<Parameter Name="kf__CaM__CaMKII" Description="independent parameter" DefaultValue="0.021"/>
<Parameter Name="kf__CaMKII_CaM_Ca3__Ca" Description="independent parameter" DefaultValue="0.04"/>
<Parameter Name="kf__CaMKII_CaM_Ca2__Ca" Description="independent parameter" DefaultValue="0.02"/>
<Parameter Name="kf__CaMKII_CaM_Ca1__Ca" Description="independent parameter" DefaultValue="0.002"/>
<Parameter Name="kf__CaMKII_CaM__Ca" Description="independent parameter" DefaultValue="0.0044"/>
<Parameter Name="kf__CaM_Ca1__CaMKII" Description="independent parameter" DefaultValue="0.021"/>
<Parameter Name="kf__CaM_Ca2__CaMKII" Description="independent parameter" DefaultValue="0.021"/>
<Parameter Name="kf__CaM_Ca3__CaMKII" Description="independent parameter" DefaultValue="0.021"/>
<Parameter Name="kf__CaM_Ca4__CaMKII" Description="independent parameter" DefaultValue="0.021"/>
<Parameter Name="KD__CaM_Ca4__CaMKII" Description="independent parameter" DefaultValue="52"/>
<Parameter Name="KD__CaMKII_CaM_Ca3__Ca" Description="independent parameter" DefaultValue="2000"/>
<Parameter Name="KD__CaMKII_CaM_Ca2__Ca" Description="independent parameter" DefaultValue="4000"/>
<Parameter Name="KD__CaMKII_CaM_Ca1__Ca" Description="independent parameter" DefaultValue="5000"/>
<Parameter Name="KD__CaMKII_CaM__Ca" Description="independent parameter" DefaultValue="2272.7"/>
<Parameter Name="kf__pCaMKII_Ca3__Ca" Description="independent parameter" DefaultValue="0.04"/>
<Parameter Name="kf__CaM__pCaMKIIaut" Description="independent parameter" DefaultValue="0.011"/>
<Parameter Name="kf__CaM_Ca1__pCaMKIIaut" Description="independent parameter" DefaultValue="0.011"/>
<Parameter Name="kf__CaM_Ca2__pCaMKIIaut" Description="independent parameter" DefaultValue="0.011"/>
<Parameter Name="kf__CaM_Ca3__pCaMKIIaut" Description="independent parameter" DefaultValue="0.011"/>
<Parameter Name="kf__pCaMKII_Ca2__Ca" Description="independent parameter" DefaultValue="0.02"/>
<Parameter Name="kf__pCaMKII_Ca1__Ca" Description="independent parameter" DefaultValue="0.002"/>
<Parameter Name="kf__CaM_Ca4__pCaMKIIaut" Description="independent parameter" DefaultValue="0.011"/>
<Parameter Name="kf__pCaMKII_Ca0__Ca" Description="independent parameter" DefaultValue="0.0044"/>
<Parameter Name="KD__pCaMKII_Ca3__Ca" Description="independent parameter" DefaultValue="2000"/>
<Parameter Name="KD__pCaMKII_Ca2__Ca" Description="independent parameter" DefaultValue="4000"/>
<Parameter Name="KD__pCaMKII_Ca1__Ca" Description="independent parameter" DefaultValue="5000"/>
<Parameter Name="KD__pCaMKII_Ca0__Ca" Description="independent parameter" DefaultValue="2272.7"/>
<Parameter Name="KD__CaM_Ca4__pCaMKIIaut" Description="independent parameter" DefaultValue="0.73"/>
<Parameter Name="kp__pairedCaMKIIc__CaMKIIc" Description="independent parameter" DefaultValue="0.05"/>
<Parameter Name="kf__PP1__pCaMKIIaut" Description="independent parameter" DefaultValue="3.9e-05"/>
<Parameter Name="kr__PP1__pCaMKIIaut" Description="independent parameter" DefaultValue="0.34"/>
<Parameter Name="kcat__PP1__pCaMKIIaut" Description="independent parameter" DefaultValue="0.086"/>
<Expression Name="KD__CaM_Ca3__PP2B" Description="Assignment" Formula="(KD__CaM_Ca3__Ca * KD__CaM_Ca4__PP2B) / KD__PP2B_CaM_Ca3__Ca"/>
<Expression Name="KD__CaM_Ca2__PP2B" Description="Assignment" Formula="(KD__CaM_Ca2__Ca * KD__CaM_Ca3__PP2B) / KD__PP2B_CaM_Ca2__Ca"/>
<Expression Name="KD__CaM_Ca1__PP2B" Description="Assignment" Formula="(KD__CaM_Ca1__Ca * KD__CaM_Ca2__PP2B) / KD__PP2B_CaM_Ca1__Ca"/>
<Expression Name="KD__CaM__PP2B" Description="Assignment" Formula="(KD__CaM__Ca * KD__CaM_Ca1__PP2B) / KD__PP2B_CaM__Ca"/>
<Expression Name="KD__CaM_Ca3__CaMKII" Description="Assignment" Formula="(KD__CaM_Ca3__Ca * KD__CaM_Ca4__CaMKII) / KD__CaMKII_CaM_Ca3__Ca"/>
<Expression Name="KD__CaM_Ca2__CaMKII" Description="Assignment" Formula="(KD__CaM_Ca2__Ca * KD__CaM_Ca3__CaMKII) / KD__CaMKII_CaM_Ca2__Ca"/>
<Expression Name="KD__CaM_Ca1__CaMKII" Description="Assignment" Formula="(KD__CaM_Ca1__Ca * KD__CaM_Ca2__CaMKII) / KD__CaMKII_CaM_Ca1__Ca"/>
<Expression Name="KD__CaM__CaMKII" Description="Assignment" Formula="(KD__CaM__Ca * KD__CaM_Ca1__CaMKII) / KD__CaMKII_CaM__Ca"/>
<Expression Name="KD__CaM_Ca3__pCaMKIIaut" Description="Assignment" Formula="(KD__CaM_Ca3__Ca * KD__CaM_Ca4__pCaMKIIaut) / KD__pCaMKII_Ca3__Ca"/>
<Expression Name="KD__CaM_Ca2__pCaMKIIaut" Description="Assignment" Formula="(KD__CaM_Ca2__Ca * KD__CaM_Ca3__pCaMKIIaut) / KD__pCaMKII_Ca2__Ca"/>
<Expression Name="KD__CaM_Ca1__pCaMKIIaut" Description="Assignment" Formula="(KD__CaM_Ca1__Ca * KD__CaM_Ca2__pCaMKIIaut) / KD__pCaMKII_Ca1__Ca"/>
<Expression Name="KD__CaM__pCaMKIIaut" Description="Assignment" Formula="(KD__CaM__Ca * KD__CaM_Ca1__pCaMKIIaut) / KD__pCaMKII_Ca0__Ca"/>
<Expression Name="kr__CaM_Ca3__Ca" Description="Assignment" Formula="KD__CaM_Ca3__Ca*kf__CaM_Ca3__Ca"/>
<Expression Name="kr__CaM_Ca2__Ca" Description="Assignment" Formula="KD__CaM_Ca2__Ca * kf__CaM_Ca2__Ca"/>
<Expression Name="kr__CaM_Ca1__Ca" Description="Assignment" Formula="KD__CaM_Ca1__Ca * kf__CaM_Ca1__Ca"/>
<Expression Name="kr__CaM__Ca" Description="Assignment" Formula="KD__CaM__Ca * kf__CaM__Ca"/>
<Expression Name="kr__CaM_Ca4__PP2B" Description="Assignment" Formula="KD__CaM_Ca4__PP2B * kf__CaM_Ca4__PP2B"/>
<Expression Name="kr__CaM_Ca3__PP2B" Description="Assignment" Formula="KD__CaM_Ca3__PP2B * kf__CaM_Ca3__PP2B"/>
<Expression Name="kr__CaM_Ca2__PP2B" Description="Assignment" Formula="KD__CaM_Ca2__PP2B * kf__CaM_Ca2__PP2B"/>
<Expression Name="kr__CaM_Ca1__PP2B" Description="Assignment" Formula="KD__CaM_Ca1__PP2B * kf__CaM_Ca1__PP2B"/>
<Expression Name="kr__CaM__PP2B" Description="Assignment" Formula="KD__CaM__PP2B * kf__CaM__PP2B"/>
<Expression Name="kr__PP2B_CaM_Ca3__Ca" Description="Assignment" Formula="KD__PP2B_CaM_Ca3__Ca *kf__PP2B_CaM_Ca3__Ca"/>
<Expression Name="kr__PP2B_CaM_Ca2__Ca" Description="Assignment" Formula="KD__PP2B_CaM_Ca2__Ca * kf__PP2B_CaM_Ca2__Ca"/>
<Expression Name="kr__PP2B_CaM_Ca1__Ca" Description="Assignment" Formula="KD__PP2B_CaM_Ca1__Ca * kf__PP2B_CaM_Ca1__Ca"/>
<Expression Name="kr__PP2B_CaM__Ca" Description="Assignment" Formula="KD__PP2B_CaM__Ca * kf__PP2B_CaM__Ca"/>
<Expression Name="kr__CaM_Ca4__CaMKII" Description="Assignment" Formula="KD__CaM_Ca4__CaMKII * kf__CaM_Ca4__CaMKII"/>
<Expression Name="kr__CaM_Ca3__CaMKII" Description="Assignment" Formula="KD__CaM_Ca3__CaMKII * kf__CaM_Ca3__CaMKII"/>
<Expression Name="kr__CaM_Ca2__CaMKII" Description="Assignment" Formula="KD__CaM_Ca2__CaMKII * kf__CaM_Ca2__CaMKII"/>
<Expression Name="kr__CaM_Ca1__CaMKII" Description="Assignment" Formula="KD__CaM_Ca1__CaMKII * kf__CaM_Ca1__CaMKII"/>
<Expression Name="kr__CaM__CaMKII" Description="Assignment" Formula="KD__CaM__CaMKII * kf__CaM__CaMKII"/>
<Expression Name="kr__CaMKII_CaM_Ca3__Ca" Description="Assignment" Formula="KD__CaMKII_CaM_Ca3__Ca * kf__CaMKII_CaM_Ca3__Ca"/>
<Expression Name="kr__CaMKII_CaM_Ca2__Ca" Description="Assignment" Formula="KD__CaMKII_CaM_Ca2__Ca * kf__CaMKII_CaM_Ca2__Ca"/>
<Expression Name="kr__CaMKII_CaM_Ca1__Ca" Description="Assignment" Formula="KD__CaMKII_CaM_Ca1__Ca * kf__CaMKII_CaM_Ca1__Ca"/>
<Expression Name="kr__CaMKII_CaM__Ca" Description="Assignment" Formula="KD__CaMKII_CaM__Ca * kf__CaMKII_CaM__Ca"/>
<Expression Name="kr__pCaMKII_Ca3__Ca" Description="Assignment" Formula="KD__pCaMKII_Ca3__Ca * kf__pCaMKII_Ca3__Ca"/>
<Expression Name="kr__pCaMKII_Ca2__Ca" Description="Assignment" Formula="KD__pCaMKII_Ca2__Ca * kf__pCaMKII_Ca2__Ca"/>
<Expression Name="kr__pCaMKII_Ca1__Ca" Description="Assignment" Formula="KD__pCaMKII_Ca1__Ca * kf__pCaMKII_Ca1__Ca"/>
<Expression Name="kr__pCaMKII_Ca0__Ca" Description="Assignment" Formula="KD__pCaMKII_Ca0__Ca * kf__pCaMKII_Ca0__Ca"/>
<Expression Name="kr__CaM_Ca4__pCaMKIIaut" Description="Assignment" Formula="KD__CaM_Ca4__pCaMKIIaut * kf__CaM_Ca4__pCaMKIIaut"/>
<Expression Name="kr__CaM_Ca3__pCaMKIIaut" Description="Assignment" Formula="KD__CaM_Ca3__pCaMKIIaut * kf__CaM_Ca3__pCaMKIIaut"/>
<Expression Name="kr__CaM_Ca2__pCaMKIIaut" Description="Assignment" Formula="KD__CaM_Ca2__pCaMKIIaut * kf__CaM_Ca2__pCaMKIIaut"/>
<Expression Name="kr__CaM_Ca1__pCaMKIIaut" Description="Assignment" Formula="KD__CaM_Ca1__pCaMKIIaut * kf__CaM_Ca1__pCaMKIIaut"/>
<Expression Name="kr__CaM__pCaMKIIaut" Description="Assignment" Formula="KD__CaM__pCaMKIIaut * kf__CaM__pCaMKIIaut"/>
<!-- Ca is set to some concentration, to be applied at t=0 -->
<Parameter Name="Ca_set" Description="Input Parameter" DefaultValue="0.0"/>
<Expression Name="logistic" Formula="1.0/(1+exp(-10*t))"/>
<Expression Name="Ca" Formula="logistic*Ca_set"/>
<!-- Output -->
<Function Name="MolCaPerMolCaM" Description="Output"
Formula="((1.0 * CaM_Ca1) + (2.0 * CaM_Ca2) + (3.0 * CaM_Ca3) + (4.0 * CaM_Ca4) + (1.0 * PP2B_CaM_Ca1) + (2.0 * PP2B_CaM_Ca2) + (3.0 * PP2B_CaM_Ca3) + (4.0 * PP2Bc) + (1.0 * (CaMKII_CaM_Ca1 + pCaMKII_Ca1)) + (2.0 * (CaMKII_CaM_Ca2 + pCaMKII_Ca2)) + (3.0 * (CaMKII_CaM_Ca3 + pCaMKII_Ca3)) + (4.0 * (CaMKIIc + pCaMKII))) / (s + CaM + CaM_Ca1 + CaM_Ca2 + CaM_Ca3 + CaM_Ca4 + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc + CaMKII_CaM + CaMKII_CaM_Ca1 + CaMKII_CaM_Ca2 + CaMKII_CaM_Ca3 + CaMKIIc + pCaMKII_Ca0 + pCaMKII_Ca1 + pCaMKII_Ca2 + pCaMKII_Ca3 + pCaMKII)"/>
<Function Name="AutoCamkiiPercentage" Description="Output"
Formula="((pCaMKII + pCaMKIIaut + pCaMKII_Ca3 + pCaMKII_Ca2 + pCaMKII_Ca1 + pCaMKII_Ca0) / (s + totalCaMKII)) * 100"/>
<Function Name="MolCaMPerMolPP2B" Description="Output"
Formula="1.0 * (PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc) / (s + PP2B + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc)"/>
<Function Name="ActivePP2BPercentage" Description="Output"
Formula="100 * ((PP2Bc) / (s + PP2B + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc))"/>
<!--
Conservation Laws:
CaM + CaM_Ca1 + CaM_Ca2 + CaM_Ca3 + CaM_Ca4 + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc + PP1 - CaMKII - pCaMKIIaut = const. (CaM_0 + PP1_0 - CaMKII_0 )
PP2B + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc = const. (PP2B_0)
CaMKII_CaM + CaMKII_CaM_Ca1 + CaMKII + CaMKII_CaM_Ca2 + CaMKII_CaM_Ca3 + CaMKIIc + pCaMKII + pCaMKIIaut + pCaMKII_Ca3 + pCaMKII_Ca2 + pCaMKII_Ca1 + pCaMKII_Ca0 - PP1 = const. (CaMKII_0-PP1_0)
PP1__pCaMKIIaut + PP1 = const. (PP1_0)
-->
<!-- PP1 = PP10 - (PP1__pCaMKIIaut) -->
<Parameter Name="PP1_0" Description="Input; initial amount of PP1" DefaultValue="0.0"/>
<Expression Name="PP1" Formula="PP1_0-PP1__pCaMKIIaut"/>
<!-- CaMKII = (CaMKII0-PP10)-(CaMKII_CaM+CaMKII_CaM_Ca1+CaMKII_CaM_Ca2+CaMKII_CaM_Ca3+CaMKIIc+pCaMKII+pCaMKIIaut+pCaMKII_Ca3+pCaMKII_Ca2+pCaMKII_Ca1+pCaMKII_Ca0-PP1) -->
<Parameter Name="CaMKII_0" Description="Input; initial amount of CaMKII" DefaultValue="0.0"/>
<Expression Name="CaMKII"
Formula="CaMKII_0 - PP1_0 - (CaMKII_CaM + CaMKII_CaM_Ca1 + CaMKII_CaM_Ca2 + CaMKII_CaM_Ca3 + CaMKIIc + pCaMKII + pCaMKIIaut + pCaMKII_Ca3 + pCaMKII_Ca2 + pCaMKII_Ca1 + pCaMKII_Ca0 - PP1)"/>
<!-- CaM = (CaM0 + PP10 - CaMKII0) - (CaM_Ca1 + CaM_Ca2 + CaM_Ca3 + CaM_Ca4 + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc + PP1 - CaMKII - pCaMKIIaut) -->
<Parameter Name="CaM_0" Description="Input; initial amount of CaM" DefaultValue="0.0"/>
<Expression Name="CaM" Description="CaM ammounts derived from conservation relations"
Formula="CaM_0 + PP1_0 - CaMKII_0 - (CaM_Ca1 + CaM_Ca2 + CaM_Ca3 + CaM_Ca4 + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc + PP1 - CaMKII - pCaMKIIaut)"/>
<!-- PP2B = (PP2B0) - (PP2B + PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc) -->
<Parameter Name="PP2B_0" Description="Input; initial amount of PP2B" DefaultValue="0.0"/>
<Expression Name="PP2B" Description="PP2B ammounts derived from conservation relations"
Formula="PP2B_0-(PP2B_CaM + PP2B_CaM_Ca1 + PP2B_CaM_Ca2 + PP2B_CaM_Ca3 + PP2Bc)"/>
<!-- collections of variables -->
<Expression Name="totalCaMKII" Description="Assignment"
Formula="(CaMKII_CaM + CaMKII_CaM_Ca1 + CaMKII + CaMKII_CaM_Ca2 + CaMKII_CaM_Ca3 + CaMKIIc + pCaMKII + pCaMKIIaut + pCaMKII_Ca3 + pCaMKII_Ca2 + pCaMKII_Ca1 + pCaMKII_Ca0)"/>
<Expression Name="ActiveCaMKII" Description="Assignment" Formula="pCaMKII + pCaMKIIaut + pCaMKII_Ca3 + pCaMKII_Ca2 + pCaMKII_Ca1 + pCaMKII_Ca0 + CaMKIIc"/>
<!-- Hexamere reaction -->
<Constant Name="a" Description="gnuplot fit constant, uncertainty: +-0.035" Value="3.90264"/>
<Constant Name="b" Description="gnuplot fit constant, uncertainty: +-0.033" Value="2.86972"/>
<Expression Name="r" Formula="(CaMKIIc+pCaMKII)/(s+totalCaMKII)"/>
<Expression Name="pairedCaMKIIc" Description="Assignment" Formula="a*(r*r)/(1+b*r)"/>
<!-- Fluxes -->
<Expression Name="ReactionFlux1" Description="Flux" Formula="(kf__CaM__Ca*Ca*CaM)-(kr__CaM__Ca*CaM_Ca1)"/>
<Expression Name="ReactionFlux2" Description="Flux" Formula="(kf__CaM_Ca1__Ca*Ca*CaM_Ca1)-(kr__CaM_Ca1__Ca*CaM_Ca2)"/>
<Expression Name="ReactionFlux3" Description="Flux" Formula="(kf__CaM_Ca2__Ca*Ca*CaM_Ca2)-(kr__CaM_Ca2__Ca*CaM_Ca3)"/>
<Expression Name="ReactionFlux4" Description="Flux" Formula="(kf__CaM_Ca3__Ca*CaM_Ca3*Ca)-(kr__CaM_Ca3__Ca*CaM_Ca4)"/>
<Expression Name="ReactionFlux5" Description="Flux" Formula="(kf__CaM__PP2B*CaM*PP2B)-(kr__CaM__PP2B*PP2B_CaM)"/>
<Expression Name="ReactionFlux6" Description="Flux" Formula="(kf__CaM_Ca1__PP2B*CaM_Ca1*PP2B)-(kr__CaM_Ca1__PP2B*PP2B_CaM_Ca1)"/>
<Expression Name="ReactionFlux7" Description="Flux" Formula="(kf__CaM_Ca2__PP2B*CaM_Ca2*PP2B)-(kr__CaM_Ca2__PP2B*PP2B_CaM_Ca2)"/>
<Expression Name="ReactionFlux8" Description="Flux" Formula="(kf__CaM_Ca3__PP2B*CaM_Ca3*PP2B)-(kr__CaM_Ca3__PP2B*PP2B_CaM_Ca3)"/>
<Expression Name="ReactionFlux9" Description="Flux" Formula="(kf__CaM_Ca4__PP2B*CaM_Ca4*PP2B)-(kr__CaM_Ca4__PP2B*PP2Bc)"/>
<Expression Name="ReactionFlux10" Description="Flux" Formula="(kf__PP2B_CaM__Ca*PP2B_CaM*Ca)-(kr__PP2B_CaM__Ca*PP2B_CaM_Ca1)"/>
<Expression Name="ReactionFlux11" Description="Flux" Formula="(kf__PP2B_CaM_Ca1__Ca*PP2B_CaM_Ca1*Ca)-(kr__PP2B_CaM_Ca1__Ca*PP2B_CaM_Ca2)"/>
<Expression Name="ReactionFlux12" Description="Flux" Formula="(kf__PP2B_CaM_Ca2__Ca*PP2B_CaM_Ca2*Ca)-(kr__PP2B_CaM_Ca2__Ca*PP2B_CaM_Ca3)"/>
<Expression Name="ReactionFlux13" Description="Flux" Formula="(kf__PP2B_CaM_Ca3__Ca*PP2B_CaM_Ca3*Ca)-(kr__PP2B_CaM_Ca3__Ca*PP2Bc)"/>
<Expression Name="ReactionFlux14" Description="Flux" Formula="(kf__CaM__CaMKII*CaM*CaMKII)-(kr__CaM__CaMKII*CaMKII_CaM)"/>
<Expression Name="ReactionFlux15" Description="Flux" Formula="(kf__CaM_Ca1__CaMKII*CaM_Ca1*CaMKII)-(kr__CaM_Ca1__CaMKII*CaMKII_CaM_Ca1)"/>
<Expression Name="ReactionFlux16" Description="Flux" Formula="(kf__CaM_Ca2__CaMKII*CaM_Ca2*CaMKII)-(kr__CaM_Ca2__CaMKII*CaMKII_CaM_Ca2)"/>
<Expression Name="ReactionFlux17" Description="Flux" Formula="(kf__CaM_Ca3__CaMKII*CaM_Ca3*CaMKII)-(kr__CaM_Ca3__CaMKII*CaMKII_CaM_Ca3)"/>
<Expression Name="ReactionFlux18" Description="Flux" Formula="(kf__CaM_Ca4__CaMKII*CaM_Ca4*CaMKII)-(kr__CaM_Ca4__CaMKII*CaMKIIc)"/>
<Expression Name="ReactionFlux19" Description="Flux" Formula="(kf__CaMKII_CaM__Ca*Ca*CaMKII_CaM)-(kr__CaMKII_CaM__Ca*CaMKII_CaM_Ca1)"/>
<Expression Name="ReactionFlux20" Description="Flux" Formula="(kf__CaMKII_CaM_Ca1__Ca*CaMKII_CaM_Ca1*Ca)-(kr__CaMKII_CaM_Ca1__Ca*CaMKII_CaM_Ca2)"/>
<Expression Name="ReactionFlux21" Description="Flux" Formula="(kf__CaMKII_CaM_Ca2__Ca*CaMKII_CaM_Ca2*Ca)-(kr__CaMKII_CaM_Ca2__Ca*CaMKII_CaM_Ca3)"/>
<Expression Name="ReactionFlux22" Description="Flux" Formula="(kf__CaMKII_CaM_Ca3__Ca*CaMKII_CaM_Ca3*Ca)-(kr__CaMKII_CaM_Ca3__Ca*CaMKIIc)"/>
<Expression Name="ReactionFlux23" Description="Flux" Formula="(kf__CaM_Ca4__pCaMKIIaut*CaM_Ca4*pCaMKIIaut)-(kr__CaM_Ca4__pCaMKIIaut*pCaMKII)"/>
<Expression Name="ReactionFlux24" Description="Flux" Formula="(kf__CaM_Ca3__pCaMKIIaut*CaM_Ca3*pCaMKIIaut)-(kr__CaM_Ca3__pCaMKIIaut*pCaMKII_Ca3)"/>
<Expression Name="ReactionFlux25" Description="Flux" Formula="(kf__CaM_Ca2__pCaMKIIaut*CaM_Ca2*pCaMKIIaut)-(kr__CaM_Ca2__pCaMKIIaut*pCaMKII_Ca2)"/>
<Expression Name="ReactionFlux26" Description="Flux" Formula="(kf__CaM_Ca1__pCaMKIIaut*CaM_Ca1*pCaMKIIaut)-(kr__CaM_Ca1__pCaMKIIaut*pCaMKII_Ca1)"/>
<Expression Name="ReactionFlux27" Description="Flux" Formula="(kf__CaM__pCaMKIIaut*CaM*pCaMKIIaut)-(kr__CaM__pCaMKIIaut*pCaMKII_Ca0)"/>
<Expression Name="ReactionFlux28" Description="Flux" Formula="(kf__pCaMKII_Ca0__Ca*pCaMKII_Ca0*Ca)-(kr__pCaMKII_Ca0__Ca*pCaMKII_Ca1)"/>
<Expression Name="ReactionFlux29" Description="Flux" Formula="(kf__pCaMKII_Ca1__Ca*pCaMKII_Ca1*Ca)-(kr__pCaMKII_Ca1__Ca*pCaMKII_Ca2)"/>
<Expression Name="ReactionFlux30" Description="Flux" Formula="(kf__pCaMKII_Ca2__Ca*pCaMKII_Ca2*Ca)-(kr__pCaMKII_Ca2__Ca*pCaMKII_Ca3)"/>
<Expression Name="ReactionFlux31" Description="Flux" Formula="(kf__pCaMKII_Ca3__Ca*pCaMKII_Ca3*Ca)-(kr__pCaMKII_Ca3__Ca*pCaMKII)"/>
<Expression Name="ReactionFlux32" Description="Flux" Formula="(kp__pairedCaMKIIc__CaMKIIc*pairedCaMKIIc*CaMKIIc)"/>
<Expression Name="ReactionFlux33" Description="Flux" Formula="(kf__PP1__pCaMKIIaut*pCaMKIIaut*PP1)-(kr__PP1__pCaMKIIaut*PP1__pCaMKIIaut)"/>
<Expression Name="ReactionFlux34" Description="Flux" Formula="(kcat__PP1__pCaMKIIaut*PP1__pCaMKIIaut)"/>
<StateVariable Name="CaM_Ca1"
Formula="(ReactionFlux1 - ReactionFlux2 - ReactionFlux6 - ReactionFlux15 - ReactionFlux26)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaM_Ca2"
Formula="(ReactionFlux2 - ReactionFlux3 - ReactionFlux7 - ReactionFlux16 - ReactionFlux25)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaM_Ca3"
Formula="(ReactionFlux3 - ReactionFlux4 - ReactionFlux8 - ReactionFlux17 - ReactionFlux24)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaM_Ca4"
Formula="(ReactionFlux4 - ReactionFlux9 - ReactionFlux18 - ReactionFlux23)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="PP2B_CaM"
Formula="(ReactionFlux5 - ReactionFlux10)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="PP2B_CaM_Ca1"
Formula="(ReactionFlux6 + ReactionFlux10 - ReactionFlux11)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="PP2B_CaM_Ca2"
Formula="(ReactionFlux7 + ReactionFlux11 - ReactionFlux12)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="PP2B_CaM_Ca3"
Formula="(ReactionFlux8 + ReactionFlux12 - ReactionFlux13)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="PP2Bc"
Formula="(ReactionFlux9 + ReactionFlux13)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaMKII_CaM"
Formula="(ReactionFlux14 - ReactionFlux19)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaMKII_CaM_Ca1"
Formula="(ReactionFlux15 + ReactionFlux19 - ReactionFlux20)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaMKII_CaM_Ca2"
Formula="(ReactionFlux16 + ReactionFlux20 - ReactionFlux21)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaMKII_CaM_Ca3"
Formula="(ReactionFlux17 + ReactionFlux21 - ReactionFlux22)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="CaMKIIc"
Formula="(ReactionFlux18 + ReactionFlux22 - ReactionFlux32)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="pCaMKII"
Formula="(ReactionFlux23 + ReactionFlux31 + ReactionFlux32)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="pCaMKIIaut"
Formula="(-ReactionFlux23 - ReactionFlux24 - ReactionFlux25 - ReactionFlux26 - ReactionFlux27 - ReactionFlux33)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="pCaMKII_Ca3"
Formula="(ReactionFlux24 + ReactionFlux30 - ReactionFlux31)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="pCaMKII_Ca2"
Formula="(ReactionFlux25 + ReactionFlux29 - ReactionFlux30)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="pCaMKII_Ca1"
Formula="(ReactionFlux26 + ReactionFlux28 - ReactionFlux29)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="pCaMKII_Ca0"
Formula="(ReactionFlux27 - ReactionFlux28)"
DefaultInitialCondition="0.0"/>
<StateVariable Name="PP1__pCaMKIIaut"
Formula="(ReactionFlux33 - ReactionFlux34)"
DefaultInitialCondition="0.0"/>
</VectorField>