Update tissue-networks.rst

docs/tissue-networks.rst

@@ -25,6 +25,3 @@ Examination of the genes whose expression was significantly upregulated at 2 h a
 .. figure:: http://www.nature.com/ng/journal/v47/n6/images/ng.3259-F2.jpg
 
    We anticipated that the genes most tightly connected to IL1B in the blood vessel network would be among those responding to IL-1β stimulation in blood vessel cells (a) The 20 genes most tightly connected to IL1B in the blood vessel network are shown. These genes are predicted to respond to IL-1β stimulation in blood vessel. (b) The bar plot shows the differential expression levels of the 20 IL1B neighbors measured in a microarray experiment at 0 h and 2 h after IL-1β stimulation in HASMCs, which constitute most of the blood vessel. Each bar represents the gene's log ratio of mean expression at 2 h over its mean expression at 0 h. Error bars represent regularized pooled standard errors estimated by LIMMA (n = 4 biological replicates). Eighteen of the 20 IL1B network neighbors (labeled in bold) were found to be among the most significantly differentially expressed genes at 2 h relative to 0 h (P = 1.95 × 10−23).
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- Greene CS*, Krishnan A*, Wong AK*, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, Chasman DI, FitzGerald GA, Dolinski K, Grosser T, Troyanskaya OG. (2015). `Understanding multicellular function and disease with human tissue-specific networks <http://www.nature.com/ng/journal/v47/n6/full/ng.3259.html>`_. Nature Genetics. 10.1038/ng.3259w.