title | author | date | package | output | ||||||||||
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Introduction to ELVAR |
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2023-04-27 |
ELVAR |
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ELVAR is an R-package for differential abundance (DA) testing of cell-types in single-cell RNA-Seq data. It implements an Extended Louvain clustering Algorithm (EVA) that takes cell attribute information into acccount when inferring cellular communities from the cell-cell nearest neighbour graph. By taking cell attribute information into account, improved community detection is possible, which improves the power to detect DA-shifts of cell-types in relation to disease risk factors or disease itself.
To install:
library(devtools)
devtools::install_github("aet21/ELVAR")
Cell-attribute aware community detection improves differential abundance testing from single-cell RNA-Seq data. Alok K Maity, Andrew E Teschendorff. Submitted 2022.