Burden Heritability Regression (BHR) is a method to estimate the heritability explained by mutational burden in each gene, as well as gene-set enrichments and burden genetic correlations. BHR is described in detail in here. Please cite the BHR paper if you use this software in your work.

Setting up BHR on your machine

This repository contains the BHR code. To download into an R session, run: devtools::install_github("ajaynadig/bhr")

Documentation

For documentation and example BHR workflows, please see the wiki. Be sure not to miss the page on eight common BHR missteps – and how to avoid them.

We have also published other detailed scripts in the example folder, including scripts for downloading variant-level summary statistics from Genebass, scripts for running BHR, and scripts for generating the figures in the manuscript. Scripts for running the simulations in the manuscript are in the MATLAB folder.