Mu-8 (from 'mutate') is our approach to uncover which mutation of an amino-acid sequence causes a functional breakdown in a protein. Mu-8 was conceived as a contribution to the 2013 BioVis Contest and was originally developed with students of Harvard's CS 171 - Visualization class.
Mu-8 visualizes differences of principal components of a mutated protein relative to its protein family, in addition to the conservation of regions of the sequence, 3D structure and proximity data.
Johnathan D Mercer, Balaji Pandian, Alexander Lex, Nicolas Bonneel, and Hanspeter Pfister: Mu-8: Visualizing Differences between Proteins and their Families BMC Proceedings, vol. 8, no. Suppl 2, p. S5, 2014.
Johnathan Mercer (mercer at fas.harvard.edu)
Balaji Pandian (balajipandian at college.harvard.edu)
Alexander Lex (alex at seas.harvard.edu)
Nicolas Bonneel (nbonneel at seas.harvard.edu)
Hanspeter Pfister (pfister at seas.harvard.edu)