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Update MetaAnalysis_01_GingerALE.rst
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andrewjahn committed Aug 2, 2023
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Expand Up @@ -105,4 +105,16 @@ Replicating the Meta-Analysis of Kumar et al., 2016

Having used GingerALE to perform a small meta-analysis, let's expand our scope by using the coordinates reported in a paper by `Kumar et al., 2016 <https://www.jneurosci.org/content/jneuro/36/15/4170.full.pdf>`__ which were drawn from several studies examining speech production. The tasks used in these studies, which are listed in Table 1 of the paper, range from saying nouns, vowels, pseudowords, and different kinds of vowel and consonant sequences.

In fact, it is this table that we will draw all of our coordinates from, in order to replicate their meta-analysis.
In fact, it is this table that we will draw all of our coordinates from, in order to replicate their meta-analysis. This may take some time to transcribe it by hand into a text file, but it is useful to do this a couple of times to get used to the feel of creating your own set of coordinates, which may not always be available in databases such as `Sleuth <https://brainmap.org/sleuth/>`__ which extract the coordinates automatically.

As you create the foci file, it should look something like this, with the original paper and the text file displayed side by side:

.. figure:: GingerALE_01_ExtractingCoordinates.png

.. note::

The Kumar et al. paper lists the space in which each set of coordinates are reported, some of which are in Talairach-Tournoux (TT) space. These coordinates can be converted to MNI using any one of the converters found online, such as `this one <https://bioimagesuiteweb.github.io/webapp/mni2tal.html>`__. Once you are done converting all of the required coordinates, create a new folder called ``Kumar_Replication``, and within that folder save the coordinates file as ``Speech_Coordinates.txt``.

From the Methods section of the paper, we learn that the authors performed their meta-analysis with GingerALE as well, using "a familywise error-corrected p = 0.01 with minimum cluster size [sic.] of 200mm^3". To replicate this we should therefore use the ``Voxel-level FWE`` correction method, setting the alpha level to ``0.01``. (The Min. Volume field should be set to ``200`` as the default, and so does not need to be changed in this case.) Then, load the foci file and click ``Compute``. This analysis should only take a few minutes.

When it is done,

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