$ [sudo] pip install django-update-sql
from django_update_sql import update_sql
qs = Table.objects.filter(pk=42)
kwargs = dict(key='value', updated_at=datetime.now())
update_sql(qs, **kwargs)
UPDATE "table" SET "key" = 'value',"updated_at" = '2020-01-23T00:49:39'::timestamp WHERE "id" = 42