This is a collection of all R-scripts used to perform DNA-methylation data analysis presented in 'Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain'.
Manuscript was published in Acta Neuropathologica Communications, https://doi.org/10.1186/s40478-022-01470-0. Raw and processed data is publicly available at NCBI GEO accession number GSE21268 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE212682
Folders:
- main_analysis: contains all scripts from data preprocessing to differential methylation analysis
- figures_and_tables: contains all scripts to reproduce tables and plots included in the publication, numbered accordingly
- functions: contains functions used in other scripts
To cite this repo or article Lang, AL., Eulalio, T., Fox, E. et al. Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain. acta neuropathol commun 10, 174 (2022). https://doi.org/10.1186/s40478-022-01470-0