Cal-Repository: Indirect calorimetry data for rodents

Datasets and code for A big-data approach to understanding metabolic rate and response to obesity in laboratory mice. 🐭 Analyses conducted in R and CalR.

Figure 1 and figure supplement 1

Figure 1: MMPC experiment: institutional variability in response to low-fat or high-fat diet. All analyses in R. Figure Supplement 1: MMPC experiment: effect of acclimation. Plots ACEG with CalR 4-group template. BDFH in R.

• Figure 1 R code
• MMPC mass data
• MMPC overall calorimetry data
• MMPC site designations
• MMPC week 11 calorimetry data
• MMPC week 0 calorimetry data
• All sites CalR file
• All sites CalR session file

Figure 2 and figure supplements 1 & 2

Figure 2: MMPC experiment: institutional variability in metabolic rate. Plots 2A-F in R. Plots 2G-L with CalR 2-group template. Figure Supplement 1: MMPC experiment: energy balance using lean mass as a covariate. All analyses in R. Figure Supplement 2: Body weight, energy balance and RER. All analyses in R.

• Figure 2 R code
• MMPC week 11 calorimetry data
• MMPC site designations
• UC Davis CalR file
• UC Davis CalR session file
• IMPC calorimetry data
• MMPC week 0 full data
• MMPC week 0 mass data

Figure 3 and figure supplements 1-3

Figure 3: IMPC experiment: institutional variability of metabolic rate. All analyses in R. Figure Supplement 1: IMPC experiment: body weight and metabolic rate. All analyses in R. Figure Supplement 2: Variation in energy expenditure for WT female and male mice. All analyses in R. Figure Supplement 3: Irregularities in the IMPC dataset. All analyses in R.

• Figure 3 R code
• IMPC calorimetry data
• IMPC "unfixed" calorimetry data

Figure 4

IMPC experiment: Comparison of three sites by sex and temperature. All analyses in R.

• Figure 4 R code
• IMPC calorimetry data

Figure 5

Reproducibility of KO phenotypes. All analyses in R.

• Figure 5 R code
• IMPC calorimetry data
• Banks Lab Cdkal1 data

Figure 6

Genetic contribution to EE. All analyses in R.

• Figure 6 R code
• IMPC calorimetry data

Figure 7

Select physiologic effects on EE. All analyses in R.

• Figure 7 R code
• Houtkooper et al. aging data
• Houtkooper et al. mass data
• O'Neal et al. exercise data
• O'Neal et al. mass data
• Banks Lab CL baseline data
• Banks Lab CL data
• Banks Lab temperature data
• Banks Lab mass data
• IMPC calorimetry data

Supplementary Table 1

• Supplementary Table 1 R code