Metformin-Feeding-Lac-Phe-Analysis

Welcome to the repository for our research showing that Metformin and meals increases the levels of the appetite-suppressing metabolite N-Lactoyl Phenylalanine (Lac-Phe). Our findings are published in Nature Metabolism as:

Metformin and feeding increase levels of the appetite suppressing metabolite Lac-Phe

Repository Structure

• notebooks/: Contains Jupyter notebooks detailing our data analysis and visualization processes.
• data/: Includes the datasets used in our study. For details on the data files and their sources, please refer to the README in the data directory.

Running the Analysis

Access our primary analysis notebooks directly on Google Colab for an interactive experience without the need for local setup:

Colab Notebook introducing our first dataset. Our first indication that Lac-Phe increased in response to metformin.

Colab Notebook for the Lac-Phe response to a mixed meal challenge

Colab Notebook for the Lac-Phe response to a Date fruit challenge

For any inquiries, please open an issue or contact barry.f.scott@gamil.com