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This is code for a parametric bootstrap for use in gene-set GE interaction analysis

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Parametric_Bootstrap for gene-set GE interaction analysis

Paper: Application of the parametric bootstrap for gene-set analysis of gene-environment interactions. Coombes BJ, Biernacka, JM. 2017. In preparation

Description: Provides a method to correct inflated type I error for Gamma (and Fisher's) method in a gene-set GE interaction analysis.

Requirements: Downloaded parallel R package from CRAN (optional) Downloaded GMMAT R package from https://content.sph.harvard.edu/xlin/software.html#gmmat

Notes: This code tests GE interaction at the gene-level using the PC method. Users may use other gene-level tests by substituting their function where lrtest.GE() is in the code.

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This is code for a parametric bootstrap for use in gene-set GE interaction analysis

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