Scripts for COVID-19 time series scRNA seq analysis using metacells.

A collection of scripts and associated metadata for regression-based analysis of PBMC expression changes through time. 4 scripts are related to maSigPro analysis by cell type for SEACells metacells, random metacells, all cells, and pseudobulked samples. 1 script is related to analysis of SEACells metacell purity. 1 Python script for creating metacells by time point.

Ref: O'Leary K and Zheng D. (2024) Metacell-based differential expression analysis identifies cell type specific temporal gene response programs in COVID-19 patient PBMCs. npj Systems Biology and Application