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Mappings to pathway ontology #36

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cthoyt opened this issue Dec 30, 2020 · 0 comments
Open

Mappings to pathway ontology #36

cthoyt opened this issue Dec 30, 2020 · 0 comments

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@cthoyt
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cthoyt commented Dec 30, 2020

From the Pathway Ontology OBO, it seems that there are xrefs to SMP (the small molecule pathway database) but neither using the appropriate OBO context. First, they appear as CURIEs in synonyms:

[Term]
id: PW:0002615
name: glyoxalase metabolic pathway
def: "The glyoxalase pathway is the main detoxifying  route to protect against the harmful effects of methylglyoxal (MG). The highly reactive dicarbonyl compound is primarily a by-product of glycolysis, but  it can also result as a by-product of fatty acid and protein metabolism. MG is also known as pyruvaldehyde or 2-oxopropanol." [PMID:23763312, PMID:25709564]
synonym: "2-oxo propanol degradation pathway" RELATED []
synonym: "methylglyoxal degradation pathway" RELATED []
synonym: "pyruvaldehyde degradation pathway" RELATED []
synonym: "SMP:00459" RELATED []
is_a: PW:0000063 ! glyoxylate and dicarboxylate metabolic pathway
created_by: vpetri
creation_date: 2016-08-08T09:55:16Z

Second, they're appearing in alt ids:

[Term]
id: PW:0000069
name: ketone bodies metabolic pathway
alt_id: KEGG:00072
alt_id: Reactome:R-HSA-74182
alt_id: SMP:00071
def: "Those metabolic reactions involved in the synthesis, utilization or degradation of ketone bodies. The chemicals acetoacetate, acetone and beta-hydroxybutyrate are collectively known as ketone bodies, although only the first two are ketones. They provide fuel for heart and skeletal muscle and for the brain during starvation. Excessive accumulation of these acidic chemicals leads to dangerous diabetic conditions known as ketoacidosis." [GO:0046950, KEGG:map00072, MCW Libraries:QU4 V876f 2008, OneLook:www.onelook.com]
comment: The definition was compiled using the information from a number of biological/medical dictionaries available at OneLook
synonym: "Ketone body metabolism" RELATED []
is_a: PW:0000058 ! fatty acid metabolic pathway

It looks like there's quite a bit of nice information here, even though its not organized well

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