boto.ec2.connection.EC2Connection should have a way to modify a network interface attribute.
I agree - I'm trying to change the "source/dest check" of an interface that I've created with boto, but am having very little luck.
New method: modify_network_interface_attribute
Adding the modify_network_interface_attribute method on ec2 connection.
Allows users to modify various attributes of an ENI.
Addresses issue #1426