Provides the p-value for a joint test of association between a phenotype and a set of genetic variants (SNPs) by combining marginal p-values using the Fisher method. See Fisher, R.A. (1925) Statistical Methods for Research Workers.
library(devtools)
install_github("carlosgarciaprieto/GSAfisherCombined")Default method of GSAfisher function that computes the p-value for a joint test of association between a phenotype and a set of genetic variants (SNPs) by combining marginal p-values using the Fisher method.
## Default S3 method:
GSAfisher(x,...)x = Numeric set of marginal p-values (one vector or a sinlge p-value).
... = Further arguments passed to or from other methods.p = Fisher method combined p-value.#Generate 1000 random values from an Uniform distribution U (0, 0.25).
x<-runif(1000, 0, 0.25)
#Apply the GSAfisher.default function to this data vector.
GSAfisher(x)