i18ndude performs various tasks related to ZPT's, Python Scripts and i18n.
i18ndude works with Python 2.6 and 2.7. It is expected to work with Python 2.4 and 2.5 too, but it may be tricky to get the proper versions of its dependencies that work with those Python versions.
i18ndude uses a few zope packages. If you install i18ndude using a buildout, you may want to pin their versions to the ones in the current latest ztk (Zope Tool Kit) versions, as that is what we test with: http://download.zope.org/zopetoolkit/index/1.1.6/ztk-versions.cfg
If you use a separate buildout for i18ndude, you may want to update the zope.tal version to 4.0.0 or higher, with fixes a possible UnicodeDecodeError while printing a warning when a msgid already exists. If you happen to hit that corner case, the new version should help.
If you add i18ndude to a buildout that handles a Zope, CMF or Plone site, you probably already have versions pinned so then you do not need to add an extends line.
You can also use pip or easy_install to install it. With pip you may want to create a requirements.txt based on that ztk versions list.