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cellcollective-2329-1.sbml
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cellcollective-2329-1.sbml
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<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" qual:required="true" version="1" xmlns:qual="http://www.sbml.org/sbml/level3/version1/qual/version1">
<model id="M2329" metaid="d40c542b-2d32-424f-92dc-d363ea9cae7d" name="Apoptosis Network">
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<body xmlns="http://www.w3.org/1999/xhtml">To understand the design principles of the molecular interaction network associated with the irreversibility of cell apoptosis and the stability of cell surviving, we constructed a Boolean network integrating both the intrinsic and extrinsic pro-apoptotic pathways with pro-survival signal transduction pathways. We performed statistical analyses of the dependences of cell fate on initial states and on input signals. The analyses reproduced the well-known pro- and anti-apoptotic effects of key external signals and network components. We found that the external GF signal by itself did not change the apoptotic ratio from randomly chosen initial states when there is no external TNF signal, but can significantly offset apoptosis induced by the TNF signal. While a complete model produces the expected irreversibility of the apoptosis process, alternative models missing one or more of four selected inter-component connections indicate that the feedback loops directly involving the caspase 3 are essential for maintaining irreversibility of apoptosis. The feedback loops involving P53 showed compensating effects when those involving caspase 3 have been removed. The GF signal significantly increases the stability of the surviving states of the network. The apoptosis network seems to use different modules by design to control the irreversibility of the apoptosis process and the stability of the surviving states. Such a design may accommodate the needed plasticity for the network to adapt to different cellular environments: depending on the strength of external pro-surviving signals, apoptosis can be induced either easily or difficultly by pro-apoptotic signal of varying strengths, but proceed with invariable irreversibility.</body>
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<p><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/O14920" style="text-decoration: none; background-color: rgb(255, 255, 255);">O14920</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/3551" ref="ordinalpos=6&amp;ncbi_uid=3551&amp;link_uid=3551" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">IKBKB</a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3551</font></span></div></p></body>
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<qual:qualitativeSpecies metaid="_27a2f569-1fbd-4288-a604-4bf84e700b89" qual:compartment="cytosol" qual:constant="false" qual:id="S_3" qual:initialLevel="0" qual:maxLevel="1" qual:name="PIP3">
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<p><div><span style="border: 0px; outline: 0px; line-height: 17px; vertical-align: baseline; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);"><span style="line-height: 17px;"><font face="Georgia" size="2">Phosphatidylinositol Triphosphate</font></span></span></div><div><font face="Georgia" size="2"><span style="border: 0px; outline: 0px; line-height: 17px; vertical-align: baseline; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);"><span style="line-height: 17px;">PubChem ID:</span></span><span style="line-height: 19px; background-color: rgb(255, 255, 255);">&nbsp;</span><a name="cid2entrez" href="http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&amp;db=pccompound&amp;term=53480352[uid]" style="border: 0px; outline: 0px; line-height: 19px; vertical-align: baseline; margin: 0px; padding: 0px; text-decoration: none; background-color: rgb(255, 255, 255);">53480352<br/></a><span style="border: 0px; outline: 0px; line-height: 17px; vertical-align: baseline; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">Molecular Formula:</span><span style="line-height: 17px; background-color: rgb(255, 255, 255);">&nbsp;C</span><sub style="border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">47</sub><span style="line-height: 17px; background-color: rgb(255, 255, 255);">H</span><sub style="border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">86</sub><span style="line-height: 17px; background-color: rgb(255, 255, 255);">O</span><sub style="border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">22</sub><span style="line-height: 17px; background-color: rgb(255, 255, 255);">P</span><sub style="border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">4</sub><span style="line-height: 17px; background-color: rgb(255, 255, 255);">&nbsp;&nbsp;&nbsp;</span><span style="border: 0px; outline: 0px; line-height: 17px; vertical-align: baseline; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">Molecular Weight:</span><span style="line-height: 17px; background-color: rgb(255, 255, 255);">&nbsp;1127.067588&nbsp;</span></font></div><div style="font-weight: normal; font-size: 10pt; font-family: Arial, Verdana;"><span style="color: rgb(85, 85, 85); font-family: Arial, Verdana, sans-serif; font-size: 13px; line-height: 17px; background-color: rgb(255, 255, 255);"><br/></span></div></p></body>
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<p><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">TNF receptor-associated factor 2 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span>&nbsp;sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q12933" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q12933</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:</span><a href="http://www.ncbi.nlm.nih.gov/gene/7186" ref="ordinalpos=1&amp;ncbi_uid=7186&amp;link_uid=7186" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">TRAF2</span></a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">7186</span></font></div></p></body>
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<qual:qualitativeSpecies metaid="_0c1c1fb4-3ba1-4398-9f73-6e00e4ed4a4b" qual:compartment="cytosol" qual:constant="false" qual:id="S_5" qual:initialLevel="0" qual:maxLevel="1" qual:name="Apaf1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Apoptotic peptidase activating factor 1 [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><font face="Georgia" size="2">Uniprot ID:&nbsp;<a href="http://www.uniprot.org/uniprot/O14727" style="text-decoration: none; background-color: rgb(255, 255, 255);">O14727</a></font><div><font face="Georgia" size="2">Gene Name:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/gene/317" ref="ordinalpos=1&amp;ncbi_uid=317&amp;link_uid=317" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">APAF1</span></a></font></div><div><font face="Georgia" size="2">NCBI Gene ID:&nbsp;<span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">317</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_0c1c1fb4-3ba1-4398-9f73-6e00e4ed4a4b">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15865941"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12972501"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15908180"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="bb2b5de7-02e3-4597-a93e-d9bf33d457dd" qual:compartment="cytosol" qual:constant="false" qual:id="S_6" qual:initialLevel="0" qual:maxLevel="1" qual:name="Mdm2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">MDM2</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;oncogene, E3 ubiquitin protein ligase [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q00987" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q00987</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/4193" ref="ordinalpos=1&amp;ncbi_uid=4193&amp;link_uid=4193" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">MDM2</span></a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 4193</font></span></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#bb2b5de7-02e3-4597-a93e-d9bf33d457dd">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="c19b9737-e5a3-4ceb-9e56-fd86c0243b70" qual:compartment="cytosol" qual:constant="false" qual:id="S_7" qual:initialLevel="0" qual:maxLevel="1" qual:name="A20">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia">AN1-type zinc finger protein 5</font></span><div><font face="Georgia"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255);">O76080</span></font></div><div><span style="background-color: rgb(255, 255, 255);"><font face="Georgia"><br/></font></span></div><div><font face="Georgia"><span style="background-color: rgb(255, 255, 255);">alternative names:</span><span style="background-color: rgb(255, 255, 255); line-height: 16px;">Zinc finger A20 domain-containing protein 2</span></font></div><div style="font-size: 10pt; font-family: Arial, Verdana;"><br/></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#c19b9737-e5a3-4ceb-9e56-fd86c0243b70">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:42:38Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9516122"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9299557"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="bcbf1bc8-606d-42f1-bc12-23682254a7cd" qual:compartment="cytosol" qual:constant="false" qual:id="S_8" qual:initialLevel="0" qual:maxLevel="1" qual:name="Cas3">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Caspase</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;</span><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">3</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">, apoptosis-related cysteine peptidase [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P42574" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42574</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/836" ref="ordinalpos=2&amp;ncbi_uid=836&amp;link_uid=836" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">CASP3</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">836</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#bcbf1bc8-606d-42f1-bc12-23682254a7cd">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:42:38Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12110144"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:5601572"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_196bb98d-2c42-46da-bcf3-925a00826567" qual:compartment="cytosol" qual:constant="false" qual:id="S_9" qual:initialLevel="0" qual:maxLevel="1" qual:name="Apoptosis">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>programmed cell death</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_196bb98d-2c42-46da-bcf3-925a00826567">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:24:03Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="dc1b92aa-1505-4d23-9050-07f7eb94da2f" qual:compartment="cytosol" qual:constant="false" qual:id="S_10" qual:initialLevel="0" qual:maxLevel="1" qual:name="NFkB">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font size="2" face="Georgia">Referring&nbsp;to p65(RelA):p50\r\nheterodimers in this context [1].&nbsp;</font><div style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Nuclear</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;</span><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">factor</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;of kappa light polypeptide gene enhancer in B-cells 1 [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P19838" style="text-decoration: none; background-color: rgb(255, 255, 255);">P19838</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/4790" ref="ordinalpos=6&amp;ncbi_uid=4790&amp;link_uid=4790" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">NFKB1</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene ID:</span><span style="background-color: rgb(255, 255, 255); line-height: 17.77777862548828px;">4790</span></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">v-rel avian reticuloendotheliosis viral oncogene homolog A [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q04206" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q04206</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/5970" ref="ordinalpos=1&amp;ncbi_uid=5970&amp;link_uid=5970" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">RELA</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene ID:</span><span style="background-color: rgb(255, 255, 255); line-height: 17.77777862548828px;">5970</span></font></div></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#dc1b92aa-1505-4d23-9050-07f7eb94da2f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:51:06Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9516122"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9299557"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="ab7f614b-12c9-4406-ae29-e8a8ab822806" qual:compartment="cytosol" qual:constant="false" qual:id="S_11" qual:initialLevel="0" qual:maxLevel="1" qual:name="Cas9">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Caspase</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;</span><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">9</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">, apoptosis-related cysteine peptidase [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P55211" style="text-decoration: none; background-color: rgb(255, 255, 255);">P55211</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/842" ref="ordinalpos=1&amp;ncbi_uid=842&amp;link_uid=842" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">CASP9</a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 842</font></span></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#ab7f614b-12c9-4406-ae29-e8a8ab822806">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12110144"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15601572"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_473b9016-fa77-4446-b5ab-c297d542a820" qual:compartment="cytosol" qual:constant="false" qual:id="S_12" qual:initialLevel="0" qual:maxLevel="1" qual:name="TRADD">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">TNFRSF1A-associated via death domain [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span><br/></font><div><font face="Georgia"><font size="2">UniProt Accession ID:&nbsp;</font><a href="http://www.uniprot.org/uniprot/Q15628" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q15628</a></font></div><div><font face="Georgia">Gene Name:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/gene/8717" ref="ordinalpos=1&amp;ncbi_uid=8717&amp;link_uid=8717" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">TRADD</span></a></font></div><div><font face="Georgia">NCBI Gene ID:&nbsp;<span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">8717</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_473b9016-fa77-4446-b5ab-c297d542a820">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:42:38Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10629108"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_219660bd-04a2-4c41-94a4-e2117ba9c51f" qual:compartment="cytosol" qual:constant="false" qual:id="S_14" qual:initialLevel="0" qual:maxLevel="1" qual:name="TNFR1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia"><span style="line-height: 19.999780654907227px; font-size: 13.333333969116211px; background-color: rgb(255, 255, 255);">Tumor necrosis factor receptor superfamily, member 1A [</span><em style="line-height: 19.999780654907227px; font-size: 13.333333969116211px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; font-size: 13.333333969116211px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div style="line-height: normal;"><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P19438" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P19438</a></font></div><div style="line-height: normal;"><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/7132" ref="ordinalpos=2&amp;ncbi_uid=7132&amp;link_uid=7132" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">TNFRSF1A</a></font></div><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">7132</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_219660bd-04a2-4c41-94a4-e2117ba9c51f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:42:38Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10629108"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_9c124d37-0627-4876-845b-5aea6da45575" qual:compartment="cytosol" qual:constant="false" qual:id="S_15" qual:initialLevel="0" qual:maxLevel="1" qual:name="BclX">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">BCL2-like 1 [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q07817" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q07817</a><span style="background-color: rgb(255, 255, 255); line-height: 19.999780654907227px;">&nbsp;</span></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/598" ref="ordinalpos=2&amp;ncbi_uid=598&amp;link_uid=598" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">BCL2L1</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">598</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_9c124d37-0627-4876-845b-5aea6da45575">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:51:06Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16751281"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9990849"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_7ba1aafb-d1e3-43eb-8345-d5ce3df3cbaf" qual:compartment="cytosol" qual:constant="false" qual:id="S_16" qual:initialLevel="0" qual:maxLevel="1" qual:name="Cas6">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Caspase</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;</span><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">6</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">, apoptosis-related cysteine peptidase [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P55212" style="text-decoration: none; background-color: rgb(255, 255, 255);">P55212</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/839" ref="ordinalpos=2&amp;ncbi_uid=839&amp;link_uid=839" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">CASP6</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCABI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">839</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_7ba1aafb-d1e3-43eb-8345-d5ce3df3cbaf">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:42:38Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_75743c78-9342-44fd-b0c5-60920d34fadb" qual:compartment="cytosol" qual:constant="false" qual:id="S_17" qual:initialLevel="0" qual:maxLevel="1" qual:name="Cas7">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Caspase</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;</span><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">7</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">, apoptosis-related cysteine peptidase [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P55210" style="text-decoration: none; background-color: rgb(255, 255, 255);">P55210</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/840" ref="ordinalpos=1&amp;ncbi_uid=840&amp;link_uid=840" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">CASP7</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">840</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_75743c78-9342-44fd-b0c5-60920d34fadb">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12110144"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15601572"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="b48c4797-8836-41fa-aee8-13d199b74f4a" qual:compartment="cytosol" qual:constant="false" qual:id="S_18" qual:initialLevel="0" qual:maxLevel="1" qual:name="TNFR2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Tumor necrosis factor receptor superfamily, member 1B [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P20333" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P20333</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/7133" ref="ordinalpos=3&amp;ncbi_uid=7133&amp;link_uid=7133" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">TNFRSF1B</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">7133</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#b48c4797-8836-41fa-aee8-13d199b74f4a">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T14:29:29Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10629108"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_313b6fc2-fd14-4fb7-8c8b-c53e9622443f" qual:compartment="cytosol" qual:constant="false" qual:id="S_19" qual:initialLevel="0" qual:maxLevel="1" qual:name="MEKK1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase</font></span><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q13233" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q13233</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/4214" ref="ordinalpos=4&amp;ncbi_uid=4214&amp;link_uid=4214" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAP3K1</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">4214</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_313b6fc2-fd14-4fb7-8c8b-c53e9622443f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T16:16:10Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_4e67190f-5fed-40d1-a626-7ea257ffd7ed" qual:compartment="cytosol" qual:constant="false" qual:id="S_20" qual:initialLevel="0" qual:maxLevel="1" qual:name="cFLIP">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">CASP8 and FADD-like apoptosis regulator [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/O15519" style="text-decoration: none; background-color: rgb(255, 255, 255);">O15519</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/8837" ref="ordinalpos=2&amp;ncbi_uid=8837&amp;link_uid=8837" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">CFLAR</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">8837</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_4e67190f-5fed-40d1-a626-7ea257ffd7ed">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_6f1d177c-fac6-4e33-8976-69a82f221c41" qual:compartment="cytosol" qual:constant="false" qual:id="S_21" qual:initialLevel="0" qual:maxLevel="1" qual:name="AKT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><br/></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_6f1d177c-fac6-4e33-8976-69a82f221c41">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15784165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="f03497b7-ba5e-4773-95b7-21c99443d147" qual:compartment="cytosol" qual:constant="false" qual:id="S_22" qual:initialLevel="0" qual:maxLevel="1" qual:name="PI3K">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><div><font face="Georgia" size="2"><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Phosphatidylinositol</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">-4,5-bisphosphate 3-kinase, catalytic subunit alpha [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P42336" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42336</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/5290" ref="ordinalpos=1&amp;ncbi_uid=5290&amp;link_uid=5290" style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px; white-space: nowrap;">PIK3CA</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.77777862548828px;">5290</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#f03497b7-ba5e-4773-95b7-21c99443d147">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15784165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="f3c4388a-e397-45f9-93f4-ae2d2c5f1cb4" qual:compartment="cytosol" qual:constant="false" qual:id="S_23" qual:initialLevel="0" qual:maxLevel="1" qual:name="PTEN">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Phosphatase</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;and&nbsp;</span><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">tensin&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;"></span><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">homolog</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;[</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P60484" style="text-decoration: none; background-color: rgb(255, 255, 255);">P60484</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name:</span><a href="http://www.ncbi.nlm.nih.gov/gene/5728" ref="ordinalpos=1&amp;ncbi_uid=5728&amp;link_uid=5728" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">PTEN</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.77777862548828px;">&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.77777862548828px;">5728</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#f3c4388a-e397-45f9-93f4-ae2d2c5f1cb4">
<dcterms:modified rdf:parseType="Resource">
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</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16274701"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16545436"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_5bc3a488-7c03-41a3-8b3c-e797e82224f4" qual:compartment="cytosol" qual:constant="false" qual:id="S_24" qual:initialLevel="0" qual:maxLevel="1" qual:name="JNK">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Mitogen-activated protein kinase 8 [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P45983" style="text-decoration: none; background-color: rgb(255, 255, 255);">P45983</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/5599" ref="ordinalpos=5&amp;ncbi_uid=5599&amp;link_uid=5599" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAPK8</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.77777862548828px;">5599</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_5bc3a488-7c03-41a3-8b3c-e797e82224f4">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9529147"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10958661"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_78af8a84-b5b6-47b3-b5d1-7007be7bcd69" qual:compartment="cytosol" qual:constant="false" qual:id="S_25" qual:initialLevel="0" qual:maxLevel="1" qual:name="Mito">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2">Represents the release of apoptotic signals from the mitochondria [1].&nbsp;</font></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_78af8a84-b5b6-47b3-b5d1-7007be7bcd69">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:42:38Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15865941"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12972501"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15908180"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="f696f2b3-7a45-4995-b3bc-23681524f113" qual:compartment="cytosol" qual:constant="false" qual:id="S_26" qual:initialLevel="0" qual:maxLevel="1" qual:name="JNKK">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Mitogen-activated protein kinase kinase 4 [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P45985" style="text-decoration: none; background-color: rgb(255, 255, 255);">P45985</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/6416" ref="ordinalpos=2&amp;ncbi_uid=6416&amp;link_uid=6416" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAP2K4</a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 6416</font></span></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#f696f2b3-7a45-4995-b3bc-23681524f113">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9529147"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10958661"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="a8d789a5-9cbb-4661-b523-a8d94e5776b6" qual:compartment="cytosol" qual:constant="false" qual:id="S_27" qual:initialLevel="0" qual:maxLevel="1" qual:name="p53">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Tumor protein&nbsp;</span><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">p53</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">[</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/P04637" style="text-decoration: none; background-color: rgb(255, 255, 255);">P04637</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/7157" ref="ordinalpos=2&amp;ncbi_uid=7157&amp;link_uid=7157" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">TP53</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">7157</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#a8d789a5-9cbb-4661-b523-a8d94e5776b6">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T15:42:38Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15865941"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9529147"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12972501"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15908180"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10958661"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_41de9095-9ede-464d-898e-fb92400d82c3" qual:compartment="cytosol" qual:constant="false" qual:id="S_28" qual:initialLevel="0" qual:maxLevel="1" qual:name="TRAF">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">TNF receptor-associated factor 1 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span>&nbsp;sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:</span><a href="http://www.uniprot.org/uniprot/Q13077" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q13077</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:</span><a href="http://www.ncbi.nlm.nih.gov/gene/7185" ref="ordinalpos=1&amp;ncbi_uid=7185&amp;link_uid=7185" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">TRAF1</span></a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">7185</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_41de9095-9ede-464d-898e-fb92400d82c3">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-07-19T10:59:00Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10629108"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="a647b231-5b70-4a3c-80d7-50eab9b92bb1" qual:compartment="cytosol" qual:constant="false" qual:id="S_29" qual:initialLevel="0" qual:maxLevel="1" qual:name="BAD">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">BCL2-associated agonist of cell death [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q92934" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q92934</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/572" ref="ordinalpos=1&amp;ncbi_uid=572&amp;link_uid=572" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">BAD</span></a></font></div><div><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene ID: 572</font></span></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#a647b231-5b70-4a3c-80d7-50eab9b92bb1">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T19:54:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10365962"/>
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</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_4050d50b-9a3b-4f0f-9813-1eaf8d201028" qual:compartment="cytosol" qual:constant="false" qual:id="S_30" qual:initialLevel="0" qual:maxLevel="1" qual:name="RIP">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Receptor (TNFRSF)-interacting serine-threonine kinase 1 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span>&nbsp;sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q13546" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q13546</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/8737" ref="ordinalpos=1&amp;ncbi_uid=8737&amp;link_uid=8737" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">RIPK1</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID:&nbsp;</span><span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">8737</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_4050d50b-9a3b-4f0f-9813-1eaf8d201028">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-10-13T16:16:10Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9529147"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10958661"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="ae69804f-1a46-40dd-8f6f-e46c908aaa2a" qual:compartment="cytosol" qual:constant="false" qual:id="S_31" qual:initialLevel="0" qual:maxLevel="1" qual:name="BID">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">BH3 interacting domain death agonist [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;(human)]</span></font></div><div><font face="Georgia" size="2">UniProt Accession ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P55957" style="text-decoration: none; background-color: rgb(255, 255, 255);">P55957<br/></a><font>Gene Name:&nbsp;</font><a href="http://www.ncbi.nlm.nih.gov/gene/637" ref="ordinalpos=1&amp;ncbi_uid=637&amp;link_uid=637" style="color: rgb(100, 42, 143); line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">BID</span></a></font></div><div><font face="Georgia" size="2">Gene ID: 637</font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#ae69804f-1a46-40dd-8f6f-e46c908aaa2a">
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15865941"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12110144"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="eda359f9-b7a1-4405-a683-fdcdb6a712ef" qual:compartment="cytosol" qual:constant="false" qual:id="S_32" qual:initialLevel="0" qual:maxLevel="1" qual:name="Cas8">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2"><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Caspase</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">&nbsp;8, apoptosis-related cysteine peptidase [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q14790" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q14790</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/841" ref="ordinalpos=2&amp;ncbi_uid=841&amp;link_uid=841" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">CASP8</a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 841</font></span></div></p></body>
</notes>
<annotation>
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<rdf:Description rdf:about="#eda359f9-b7a1-4405-a683-fdcdb6a712ef">
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<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11464214"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10958661"/>
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</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9529147"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15861135"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15601572"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:8943045"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15485624"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="b6836db8-d4c4-40d0-847c-144068721ec5" qual:compartment="cytosol" qual:constant="false" qual:id="S_33" qual:initialLevel="0" qual:maxLevel="1" qual:name="FADD">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Fas (TNFRSF6)-associated via death domain [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><font face="Georgia" size="2">Uniprot ID:&nbsp;Q13158</font><div><font face="Georgia" size="2">Gene Name:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/gene/8772" ref="ordinalpos=1&amp;ncbi_uid=8772&amp;link_uid=8772" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">FADD</span></a></font></div><div><font face="Georgia" size="2">NCBI Gene ID:&nbsp;<span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">8772</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#b6836db8-d4c4-40d0-847c-144068721ec5">
<dcterms:modified rdf:parseType="Resource">
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</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:10629108"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
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</rdf:Description>
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</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_39181f50-aa0f-45d6-aa12-4c453c1707f0" qual:compartment="cytosol" qual:constant="false" qual:id="S_34" qual:initialLevel="0" qual:maxLevel="1" qual:name="APC">
<notes>
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<p><font face="Georgia" size="2" style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">This node represents the&nbsp;apoptosome complex [1]. Information about the apoptosome at (</font><font face="Georgia" size="2"><a href="http://www.ncbi.nlm.nih.gov/mesh/?term=apoptosome">http://www.ncbi.nlm.nih.gov/mesh/?term=apoptosome</a>).&nbsp;</font></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_39181f50-aa0f-45d6-aa12-4c453c1707f0">
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<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
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</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_77cc1d1a-1b48-4f85-a631-57140e51fc58" qual:compartment="cytosol" qual:constant="false" qual:id="S_35" qual:initialLevel="0" qual:maxLevel="1" qual:name="NIK">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Georgia" size="2" style="background-color: rgb(255, 255, 255);"><span style="line-height: 18.88888931274414px;">Mitogen-activated protein kinase kinase kinase 14 [</span><em style="line-height: 18.88888931274414px;">Homo sapiens</em><span style="line-height: 18.88888931274414px;">(human)]</span></font><div><font face="Georgia" size="2" style="background-color: rgb(255, 255, 255);"><span style="line-height: 18.88888931274414px;">UniProt ID:&nbsp;</span><a href="http://www.uniprot.org/uniprot/Q99558" style="text-decoration: none;">Q99558</a></font></div><div><font face="Georgia" size="2" style="background-color: rgb(255, 255, 255);"><span style="line-height: 18.88888931274414px;">Gene Name:&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/gene/9020" ref="ordinalpos=3&amp;ncbi_uid=9020&amp;link_uid=9020" style="line-height: 18.88888931274414px; white-space: nowrap;">MAP3K14</a></font></div><div><font face="Georgia" size="2" style="background-color: rgb(255, 255, 255);"><span style="line-height: 18.88888931274414px;">Gene ID:</span><span style="line-height: 17.77777862548828px;">9020</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_77cc1d1a-1b48-4f85-a631-57140e51fc58">
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<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>
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</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="db563b74-7a27-4fbb-9a93-cae9dff1c480" qual:compartment="cytosol" qual:constant="false" qual:id="S_36" qual:initialLevel="0" qual:maxLevel="1" qual:name="IAP">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font size="2" style="font-style: normal;" face="Georgia">baculoviral IAP repeat-containing 2 (BIRC2)</font><div style="font-style: normal;"><font face="Georgia"><font size="2">UniProt Accession ID: Q13490</font><font size="2"><br/></font></font><div><font size="2" face="Georgia"><br/></font></div><div><font face="Georgia" size="2">baculoviral IAP repeat-containing 3 (BIRC3)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: Q13489</font></div><div><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2">baculoviral IAP repeat-containing 4 (BIRC4)</font></div></div><div style="font-style: normal;"><font face="Georgia" size="2">UniProt Accession ID: P98170</font></div><div style="font-style: normal;"><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2">In the <em>Apoptosis Network</em>, IAP represents inhibitors of apoptosis [1].</font></div><div><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2">In Survival Signaling 2008 and 2011, IAP represents inhibitors of apoptosis.</font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#db563b74-7a27-4fbb-9a93-cae9dff1c480">
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<dcterms:W3CDTF>2017-10-13T15:51:06Z</dcterms:W3CDTF>
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<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19422837"/>
</rdf:Bag>