Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing

Abstract:
Conbase is a software for identification of somatic mutations in single cell DNA sequencing data exhibiting high rates of allelic dropout and at low read depth. Conbase leverages data from multiple samples in a dataset, and utilizes read phasing to call somatic single nucleotide variants and to accurately predict genotypes in whole genome amplified single cells.