Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

BM.1.1 sublineage with S:K356T and S:T572I (51 seq) #1438

Closed
silcn opened this issue Dec 16, 2022 · 0 comments
Closed

BM.1.1 sublineage with S:K356T and S:T572I (51 seq) #1438

silcn opened this issue Dec 16, 2022 · 0 comments
Labels
BA.2.75 designated recommended Recommended for designation by pango team member
Milestone

Comments

@silcn
Copy link

silcn commented Dec 16, 2022

Proposal for a sublineage of BM.1.1 (BA.2.75.3 with S:R346T and S:F486S)
Earliest seq: 2022-10-11 (India)
Countries detected: Thailand (4 seq), Belgium, Indonesia, Turkey (3 each), Israel, Singapore, USA (2 each), Canada, Denmark, Germany, India, Ireland, South Korea (1 each)

Mutations on top of BM.1.1:
S: K356T, T572I
ORF1a: S216Y, D629A
nuc: C3130T (shared with BM.1.1.3), G29527A

GISAID query: nucleotide mutations C912A, A2151C

This lineage has a lot of diversity and has turned up all over the world but there doesn't seem to be much of it in any particular place, suggesting it might be more prevalent in some undersampled area. The S:346T/356T combination is convergent with BN.1, and interestingly there are several BN.1* branches with S:T572I; it may provide a small advantage though the evidence is unclear right now.

BM11_356_572

https://nextstrain.org/fetch/github.com/silcn/subtreeAuspice1/raw/main/auspice/subtreeAuspice1_genome_2f22e_bbd1d0.json?branchLabel=Spike%20mutations&c=country&label=id:node_7730754

https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?variantQuery=nextcladePangoLineage%3ABA.2.75*+%26+%5B3-of%3A+C912A%2C+A2151C%2C+A22629C%2C+C23277T%2C+G29527A%5D&

EPI_ISLs

EPI_ISL_15398204
EPI_ISL_15486658
EPI_ISL_15710478
EPI_ISL_15724709
EPI_ISL_15733682
EPI_ISL_15778331
EPI_ISL_15781195
EPI_ISL_15904364
EPI_ISL_15927311
EPI_ISL_15928010
EPI_ISL_15928038
EPI_ISL_15973729
EPI_ISL_15999437
EPI_ISL_16074752
EPI_ISL_16087412
EPI_ISL_16093058
EPI_ISL_16093059
EPI_ISL_16097652
EPI_ISL_16109862
EPI_ISL_16111879
EPI_ISL_16111880
EPI_ISL_16121725
EPI_ISL_16121726
EPI_ISL_16122105
EPI_ISL_16129916

@silcn silcn changed the title BM.1.1 sublineage with S:K356T and S:T572I (25 seq) BM.1.1 sublineage with S:K356T and S:T572I (32 seq) Dec 26, 2022
@silcn silcn changed the title BM.1.1 sublineage with S:K356T and S:T572I (32 seq) BM.1.1 sublineage with S:K356T and S:T572I (51 seq) Jan 7, 2023
@corneliusroemer corneliusroemer added the recommended Recommended for designation by pango team member label Jan 7, 2023
@corneliusroemer corneliusroemer added this to the BM.1.1.4 milestone Jan 9, 2023
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
BA.2.75 designated recommended Recommended for designation by pango team member
Projects
None yet
Development

No branches or pull requests

3 participants