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CH.1.1.17 + S:D215G, S:Q613H(228 sequences) #1718

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DoropFan opened this issue Mar 3, 2023 · 8 comments
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CH.1.1.17 + S:D215G, S:Q613H(228 sequences) #1718

DoropFan opened this issue Mar 3, 2023 · 8 comments
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@DoropFan
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DoropFan commented Mar 3, 2023

Description
Sub-lineage of:CH.1.1(BA.2.75.3.4.1.1.1.1)
Earliest sequence:2022-12-30(New Zealand)
Countries circulating:New Zealand10, United Kingdom6, Austria4, Germany4, Australia3, Netherlands2, Switzerland1, Denmark1, France1
Sequences:32

Nucleotide mutations:C11750T,C18657T,C21811T,A22206G,G23401T,A27156G,C29555T
Amino acid changes:ORF1a:L3829F, S:D215G, S:Q613H, M:S212G
CovSpectrum

Genomes
ch11s215gs613h
ch11s215gs613h2

@DoropFan DoropFan changed the title CH.1.1 + S:D215G, S:Q613H(32sequences) CH.1.1 + S:D215G, S:Q613H(38 sequences) Mar 6, 2023
@aviczhl2
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aviczhl2 commented Mar 6, 2023

oh, this one also have the orf1a:L3829F

Screen Shot 2023-03-07 at 02 32 00

And it is quite fast even among the fastest XBB sublineages, much faster than other CH.1.1s (baseline: S:F486P)

@DoropFan
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DoropFan commented Mar 7, 2023

Correct
M:S212G>ORF1a:L3829F, S:Q613H>S:D215G
UShER Tree
ch11s215gs613h3

@DoropFan DoropFan changed the title CH.1.1 + S:D215G, S:Q613H(38 sequences) CH.1.1 + S:D215G, S:Q613H(41 sequences) Mar 7, 2023
@DoropFan DoropFan changed the title CH.1.1 + S:D215G, S:Q613H(41 sequences) CH.1.1 + S:D215G, S:Q613H(48 sequences) Mar 10, 2023
@DoropFan DoropFan changed the title CH.1.1 + S:D215G, S:Q613H(48 sequences) CH.1.1 + S:D215G, S:Q613H(60 sequences) Mar 14, 2023
@hsnguyen
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More sequences from Australia.
GISAID query (Spike_Q613H, Spike_D215G, M_S212G) returned 66 seq. now

@DoropFan DoropFan changed the title CH.1.1 + S:D215G, S:Q613H(60 sequences) CH.1.1 + S:D215G, S:Q613H(66 sequences) Mar 14, 2023
@DoropFan DoropFan changed the title CH.1.1 + S:D215G, S:Q613H(66 sequences) CH.1.1 + S:D215G, S:Q613H(69 sequences) Mar 17, 2023
@DoropFan DoropFan changed the title CH.1.1 + S:D215G, S:Q613H(69 sequences) CH.1.1 + S:D215G, S:Q613H(78 sequences) Mar 20, 2023
@hsnguyen
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I found that M_S212G is gone missing from a number of sequences within this clade due to ambiguous bases, so changed the GISAID query to (NSP6_L260F, NSP8_N118S, Spike_D215G,Spike_Q613H). This one returned 100 viruses as of 21 March.
where
NSP6_L260F = ORF1a_L3829F = C11750T
NSP8_N118S = ORF1a_N4060S = A12444G

If only searching by spike mutations of CH.1.1+ Spike_Q613H, Spike_D215G, it'll return even more seqs as about 40 Austrian partial sequences (>2Kbp spike sequencing?) would add up to the result.
I think this one deserves a name for itself, just not sure if it'd be a direct sub-lineage from CH.1.1 or something further down.
Cheers,

@corneliusroemer corneliusroemer changed the title CH.1.1 + S:D215G, S:Q613H(78 sequences) CH.1.1.17 + S:D215G, S:Q613H(78 sequences) Mar 21, 2023
@corneliusroemer
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I designated the parent lineage as CH.1.1.17 so this should become easier to track 3812bd7

@DoropFan DoropFan changed the title CH.1.1.17 + S:D215G, S:Q613H(78 sequences) CH.1.1.17 + S:D215G, S:Q613H(213 sequences) Mar 24, 2023
@DoropFan
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New Zealand
nz

@DoropFan DoropFan changed the title CH.1.1.17 + S:D215G, S:Q613H(213 sequences) CH.1.1.17 + S:D215G, S:Q613H(228 sequences) Mar 28, 2023
@FedeGueli
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it is 300 and its prent is already the fastest non - XBB lineage. @corneliusroemer @InfrPopGen i think it deserves a designation .:
Schermata 2023-03-31 alle 00 14 05

And more it has already split in two:
One branch with C27804T
and the other with Orf1a:L384F
Schermata 2023-03-31 alle 00 17 12
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_988e_609d80.json?c=userOrOld&label=id:node_8110628

@InfrPopGen InfrPopGen self-assigned this Mar 31, 2023
InfrPopGen added a commit that referenced this issue Mar 31, 2023
Added new lineage FK.1 from #1718 with 70 new sequence designations, and 89 updated from CH.1.1 and CH.1.1.17
@InfrPopGen InfrPopGen added this to the FK.1 milestone Mar 31, 2023
@InfrPopGen
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Thanks for submitting. We've added lineage FK.1 with 70 newly designated sequences, and 89 updated from CH.1.1 (30) and CH.1.1.17 (59). Defining mutation A22206G (S:D215G) (following C11750T (ORF1a:L3829F), G23401T (S:Q613H)).

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