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Very recent BQ.1.1.71 sublineage with additional Spike mutation S:Y248H apparently growing in Uk 9 seqs #1739

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FedeGueli opened this issue Mar 8, 2023 · 2 comments
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@FedeGueli
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FedeGueli commented Mar 8, 2023

While chatting with @c19850727 about BQ.1.1.71 i noticed a very recent sublineage of it defined by S:Y248H.
Being insertions/mutations at residue 248 a known tract of late fast BQ.1.1 (BQ.1.1.45,EA.1, BQ.1.1.37) and being BQ.1.1.71 i propose it to flag it immediately.

EDITED: It was spotted and monitored first by @c19850727

Tree:
Schermata 2023-03-08 alle 15 23 12
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_27ac5_899b30.json?label=id:node_6033801

Defining mutations:
BQ.1.1.71 > > A13132G > S:Y248H (T22304C)

Gisaid query:
Spike_Y248H,Spike_p251L,Spike_G446R

CovSpectrum query: S:G446R,S:Y248H (still 0)

Sequences: 9 England (8) Ireland (1)
EPI_ISL_17026965, EPI_ISL_17063443, EPI_ISL_17095002,
EPI_ISL_17098364, EPI_ISL_17153501, EPI_ISL_17153506,
EPI_ISL_17153712, EPI_ISL_17153779, EPI_ISL_17153864,

@FedeGueli
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still 9 seqs closing it.

@FedeGueli
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It got designated:

EV.1

bd69c9c

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