XBB.1.9.1 with S:F456L starting in Vietnam(66 seqs, 11 countries)

[aviczhl2]

This is the 1st XBB.1.9.1 sub-lineage with the convergent S:F456L.
From sars-cov-2-variants/lineage-proposals#27

Sub-lineage of: XBB.1.9.1
Mutations on top of XBB.1.9.1: C28846T, G2174A(orf1a:E637K), T22928C(S:456L)
GISAID query: C28846T, G2174A, T22928C

No. of seqs: 27(3 USA 4 China 7 Vietnam 1 Singapore(from Vietnam) 2 France 2 Canada 3 South Korea(1 from Vietnam) 5 Japan)

Note that all 3 green Vietnamese seqs have S:456 dropout, they're likely to also have 456L.
GISAID query for the green Vietnamese seqs: C28846T, G2174A, G1464T,-T22928C,C12890T

First seq: 17481621, 2023-3-9, Vietnam
Latest seq: 17641519, 2023-5-1 ,Canada

usher

[aviczhl2]

53 seqs now, new country of Australia and Spain(exported to South Korea).

[JosetteSchoenma]

This seems to grow quickly. Lots of new samples on the ORF1ab:G400V branch from Australia/NSW.

[FedeGueli]

ping @corneliusroemer @InfrPopGen
reason to fast designate this one

1. growing fast outside the area where emerged from
2. 456L convergent evo able to increase fitness(escape)

[InfrPopGen]

Thanks for submitting. We've added lineage FL.15 with 53 newly designated sequences, and 0 updated designations. Defining mutation T22928C (S:F456L). There's currently two adjacent clades with S:F456L on the usher tree, but as it is likely that these are really one clade, they have been designated as if monophyletic.

[AngieHinrichs]

Good catch @InfrPopGen, I'll try to fix that soon.

[FedeGueli]

One sequence got S:L455F check via G15649A, G22927T,G1464T
ID:EPI_ISL_17836859