Swedish BA.2 (+ 22792T) with S:449H (and C9430T) [500 seq, ~5% in Sweden]

[corneliusroemer]

Noticed a slowly growing BA.2 with RBD mutation S:449H in Sweden

Full definition: BA.2* + T22907C, C9430T + S:449H

Very clearly associated with Sweden, first sequenced there, then later in nearby countries. Seems to have some global spread.

Growth advantage only ~10% per week over BA.2 but still interesting due to RBD Spike mutation and presence in a potential recombinant that's popped up in Sweden.

https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=S%3A449H&nucMutations=T22907C%2CC9430T&pangoLineage=BA.2*&aaMutations1=S%3A449H&nucMutations1=T22907C%2CC9430T&pangoLineage1=BA.2*&

List of EPI_ISLs: https://lapis.cov-spectrum.org/gisaid/v1/sample/gisaid-epi-isl?dateFrom=2021-11-08&aaMutations=S%3A449H&nucMutations=T22907C%2CC9430T&pangoLineage=BA.2*&host=Human&orderBy=random

Usher tree:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_e5b4_a589c0.json?c=country&label=nuc%20mutations:T22907C

[InfrPopGen]

Thanks for submitting. We've added lineage BA.2.45 with 405 newly designated sequences, and 33 updated designations from BA.2. Defining mutation(s) T22907C (S:Y449H).