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Fast and internationally widespread BA.2.36 sublineage with S:R346T circulating in Australia but likely emerged in some downsampled area (100 seqs) #874
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Yes, quite a few sequences from travellers, mostly from Pakistan. Also a handful from Maldives, USA, Vietnam. |
Thx very much @silcn so maybe Pakistan could be a good candidate as main' reservoir' of this sublineage , also ause it has been sampled directly in Pakistan. |
Added new lineage BA.2.36.1 from #874 with 68 new sequence designations, and 1 updated designations from BA.2
Thanks for submitting. We've added lineage BA.2.36.1 with 68 newly designated sequences, and 1 updated designations from BA.2. Defining mutation G22599C (S:R346T), preceded by node with A7201G, G12278A (ORF1a:A4005T), C13197T (ORF1a:T4311I). |
Thanks @InfrPopGen i would like just tonhifhlight that there is a recent cluster of BA.2.36.1 in Pakistan carrying additional spike S:N354K mutation, 5 sequences all from the end of June. |
Thx @AngieHinrichs i noticed that BA.2.55 and BA..2.42 were moved as BA.2.36 sublineages i didnt want to bother you and other committee member so i didnt highlight that in this issue. |
Oh please do, it's very helpful when you notice problems in the tree! It's helpful for me so I can try to fix the tree, and it's helpful for others so they know to be skeptical of some branches in the tree. |
Oke! @AngieHinrichs next time i ll do for sure. |
This lineage has been redesignated as BA.2.82 (and BA.2.36.1 withdrawn). |
Withdrew BA.2.36.1 from #874 and re-designated as BA.2.82
Here i want to propose a sublineage of BA.2.36 (S:I68T) defined by A7201G Orf1a:A4005T and Orf1a:T4311I that gained another spike mutation: S:R346T and then it is showing trasmissibility comparable to BA.5 baseline since.
I think i have found this one after @silcn highlighted in an old issue that Japanese airport genomic surveillance had detected some sequences with S:346T not belonging to any of the proposed/designated ones.
The thing that hits me of this sublineage ( beyond the comparable trasmissibility with BA.5, that could represent the first 2nd gen BA.2 comeback after the well discussed and described BA.2s sublineages from India)
is its international spread with several samples whuch make me think to airport surveillance ( As Japanese, South Korea, Bahrain, Israel shown below):
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2dc5f_f13070.json?branchLabel=aa%20mutations&c=country
Not having access to Gisaid i would ask kindly some help from @c19850727 @silcn @shay671 to verify if
"Japanese contributors (2).csv
SouthKorean contributors (3).csv
Israelian contributors (4).csv
or HongKong ( HongKong/HK-HKPU-PUU038369892/2022|EPI_ISL_13694153)"
sequences are from airport surveillance and from which countries.
Covspectrum overview:
https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=orf1a%3A4005T%2Corf1a%3A4311i%2CS%3A346T&nucMutations=A7201G&
First sequence:BHR/5902364720_S19_L001/2022|ON606157.1|2022-05-05
List of Sequences (all countries):
contributors (5).csv
Countries:
In Australia where it has been circulating locally its growth disadvantage vs BA.5 is very slight:
https://cov-spectrum.org/explore/Australia/AllSamples/Past3M/variants?variantQuery=NextCladePangolineage%3ABa.5*&aaMutations1=orf1a%3A4005T%2Corf1a%3A4311i%2CS%3A346T&nucMutations1=A7201G&analysisMode=CompareToBaseline&
Elsewhere it seems more evident around -35% (Japan,Israel) but this count could represent the importation rate rather than real transmissibility .
Anyway i think this has to be highlighted and monitored publicly due the double S mutant S:68T S:346T that confers some chance to compete with BA.5 and more importantly it would be important to check if it has or had a relevant prevalence in some undersampled area. ( There are a couple of seqs from India i cant exclude it came from there too)
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