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Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantiative and population genetic insights

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filipluca/GWAS_sex_specific_fitness_and_the_X_chromosome

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Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantiative and population genetic insights

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This page contains the code underlying analyses and figures presented in 'Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantiative and population genetic insights' (Ruzicka et al. 2021, Genetics).

The code is organised into text files 1-8, which approximately follow the order of the analyses presented in the manuscript. The text files are either R scripts (.R suffix) or UNIX scripts (.sh suffix). Reproducing analyses presented in the manuscript typically requires running both R and UNIX scripts. The contents of each file are described in bullet-point form below. I have also annotated the code for clarity, but if it's insufficiently clear please e-mail me at filip.ruzicka [at] monash.edu.

1. GWAS of sex-specific fitness

2. Functional analyses of candidate loci

3. Polygenicity of fitness

4. Partitioning Va

5. Regression of effect size on MAF

6. Alternative metrics of purifying selection

7. Stationary distribution simulations

8. Theoretical predictions

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Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantiative and population genetic insights

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