Review annotations to 'regulation of cGMP metabolic/catabolic/biosynthetic process', and + and - children

[pgaudet]

This issue was brought up in the GPCR work. Similar to cAMP biosynthesis/catabolism, cGMP biosynthesis/catabolism corresponds to the reaction catalyzed by guanylate cyclase. Regulation of cGMP metabolic/catabolic/biosynthetic process probably corresponds to a pathway, as indicated in the attached figures (but not limited to those).

Therefore, we plan to obsolete the following terms. Please review your annotations to make sure that they are housed elsewhere.

• GO:0030823 | regulation of cGMP metabolic process:
  ** 9 MGI @hdrabkin
  https://docs.google.com/spreadsheets/d/1wcwEJS9ykxip2U9U5IX8wKUXhpMyUZNKOMgl2-vX1xQ/edit#gid=0

• GO:0030824 | negative regulation of cGMP metabolic process
  ** 1 RGD @slaulederkind
  https://docs.google.com/spreadsheets/d/1foE9kV1XkTqsU3Q0XON1dorLIiyn69Kkrv_aDn6MsA8/edit#gid=0

• GO:0030826 | regulation of cGMP biosynthetic process
  ** 2 dictybase @pfey03
  ** 1 UniProt removed @pgaudet
  https://docs.google.com/spreadsheets/d/1G6_HHY4-Un211XHJCHeOkxHVVCp-1AfU6r4ELsqaPWY/edit#gid=0

• GO:0030825 | positive regulation of cGMP metabolic process
  ** 2 BHF @RLovering
  ** 2 nonEXP UniProt @ggeorghiou
  https://docs.google.com/spreadsheets/d/1tef9JmVBCdJaM8fQ3SNdfEMN3XW9R8itCTmZYTgV_TU/edit#gid=0

• GO:0030827 | negative regulation of cGMP biosynthetic process
  ** 1 dictybase @pfey03
  ** 5 UniProt-EBI @pgarmiri
  https://docs.google.com/spreadsheets/d/1XlsVrj62efXgz_EUrwdvi8B2XogqTqaQxGzIVlHzMHU/edit#gid=0

• GO:0030828 | positive regulation of cGMP biosynthetic process
  ** 2BHF-UCL @RLovering
  ** 1 dictybase @pfey03
  ** 4 MGI @hdrabkin
  ** 6 RGD @slaulederkind
  ** 1 UniProt-EBI @pgarmiri
  https://docs.google.com/spreadsheets/d/1zay-kk_3F4KNelMH_AycmxID-kVMoKhO2XD7e1CLEeA/edit#gid=0

Thanks, Pascale

[pfey03]

There was only 1 annotation of each term above where Dicty is listed. Removed or changed and Done!

[hdrabkin]

@pgaudet , what specifically are the recommendations? There are none in the spreadsheets. None of the spreadsheets have the "Suggested action (by annotation review requester) " filled in. The link to the main project is not helpful as it is not clear where the topic covered in THIS ticket is ...?

[pgaudet]

Thanks for the comment @hdrabkin
I didn't look at the annotations in this case - I will and post a comment when done.

Thanks, Pascale

[slaulederkind]

RGD annotation fixed.

[bmeldal]

GO:0030828 positive regulation of cGMP biosynthetic process removed from 3 complexes.

Was co-annotated with
GO:0004383 guanylate cyclase activity
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0035556 intracellular signal transduction
which all remain.

Birgit

[pgarmiri]

UniProt annotations has been checked and changed. Only the 2 ISS are remaining that are based on the EXP of BHF. When those are fixed, these will be updated automatically.

[RLovering]

annotations used for ISS updated
All on this ticket done.

[pgaudet]

Hi @hdrabkin @slaulederkind
I provided some suggestions in the spreadsheets that are not yet completed:
https://docs.google.com/spreadsheets/d/1zay-kk_3F4KNelMH_AycmxID-kVMoKhO2XD7e1CLEeA/edit#gid=0

https://docs.google.com/spreadsheets/d/1wcwEJS9ykxip2U9U5IX8wKUXhpMyUZNKOMgl2-vX1xQ/edit#gid=0

Please check if change if you agree. Thanks, Pascale

[slaulederkind]

RGD annotations fixed.

[hdrabkin]

mgi done

[pgaudet]

Thanks everyone !