PANTHER:PTN000473190 endopeptidase activity

[hattrill]

Nicastrin PANTHER:PTN000473190 endopeptidase activity is a subunit of the gamma secretase complex that cleaves Notch receptor and APP, but it is the presenilin subunit that has the activity.

[hattrill]

@ukemi you might want to look at the annotations to MGI:1891700

[ukemi]

Changed to contributes_to.

[ValWood]

Out of curiosity, will the PAINT annotation then automagically update?

[hattrill]

I am not sure that it will get updated automatically. I am re-opening until we have a confirmation from PAINT.
I will note now, that I don't think that PAINT should propagate "contributes_to" as this qualifier has acknowledged issues with consistency of use. Ditto of coloc_with. Propagating them just amplifies the issue.

[pgaudet]

Removed annotation. (we can do 'contributes_to in PAINT but I prefer not to).

[ValWood]

I wouldn't annotate this with contribute_to anyway, since the endonuclease subunit is clearly identifiable We only use this qualifier for "emergent function of a complex"

[pgaudet]

Right