Vitamins B6 activation to pyridoxal phosphate (R-HSA-964975)

[ukemi]

• Make mouse models
• Do you really want to use the plural in the pathway name? No - fixed
• Check/change the charge states on pyridoxamine, pyridoxamine 5'-phosphate, pyridoxine 5'-phosphate, pyridoxal, 4-pyridoxate.
• R-HSA-964962 and R-HSA-964958 are both mapped to pyridoxal kinase activity but the acceptor is not pyridoxal. I have mapped them to the parent. Although I'm not sure what is correct wrt current ontology policy.
• Deepen the MF assigned to R-HSA-3204311 to [GO:0004732] pyridoxal oxidase activity.
• Do you want to include pyridoxal phosphatase (Q96GD0) in the Reactome model? I am adding it to mouse.
• I think you should review the evidence that AOX1 catalyzes the pyridoxal oxidase reaction. In mouse there are four paralogs, but cloned enzymes cannot use pyridoxal as a substrate. Conflicting data comes from a study of 'purified' Aox3. PMID:28526768 and 18981221. I have put the activity in the mouse model, but have left out a gene product.
• These pathways are really well worked out in Drosophila. @sjm41