This repo contains a conglomerate of scripts to integrate proteomic and transcriptomic data based on a genome-scale metabolic model.
Here we have two use cases:
astrocyte_contextualization.mintegrates the data to contextualize the Osorio model.astrocyte_reconstruction.mrecontructs a context-specific model of an astrocyte using Recon3D as the base.
Multi-omics integrative analysis coupled to control theory and computational simulation of a genome-scale metabolic model reveal controlling biological switches in human astrocytes under palmitic acid-induced lipotoxicity. (submitted)