SFC_obesity

About The Project

🔷 This is code for the paper "Disrupted stepwise functional brain organization in overweight individuals" (JCR 10%)
🔷 Paper link: https://www.nature.com/articles/s42003-021-02957-7
🔷 If you use this code, please cite the article.
　　Lee, Hyebin, et al. "Disrupted stepwise functional brain organization in overweight individuals." Communications Biology 5.1 (2022): 1-9.

Prerequisites

✔ We obtained data from Enhanced Nathan Kline Institute-Rockland Sample (eNKI) database.
✔ Imaging data were preprocessed using FuNP pipeline.
✔ Brain Connectivity Toolbox was used for SFC analysis.
✔ BrainSpace Toolbox was used for visualization of cortex/subcortex features.

Usage

• meanbold.m　　　　　-----　to average BOLD signal for each atlas
  
• connectivity_seed.m　　-----　to compute connectivity matrix from mean BOLD signals and define seed 　　　　　　　　　　　　　　regions
  
• stepwise_fc.m　　　　　-----　to construct stepwise connectivity matrix
  
• group_analysis.m　　　-----　to perform group analysis using degree of SFC
  
• TFEQ_association.m　　-----　to associate degree of SFC with TFEQ scores
  
• main_figures.m　　　　-----　to plot the results of group analysis
  
  

Directory Structure

├── data
│   ├── README.md
│   ├── a_dataset.mat
│   ├── a_TFEQ_scores.mat
│   ├── cluster_Fan_Net_r280.mat
│   └── cool_warm.mat
├── sensitivity
│   ├── README.md
│   ├── bootstrap_approach.m
│   ├── control_age_sex.m
│   ├── control_TFEQ.m
│   └── high_low_risk.py
├── utils
│   ├── README.md
│   ├── binarize_conn.m
│   ├── compute_sfc.m
│   └── mean_subcortical.m
├── README.md
├── meanbold.m
├── connectivity_seed.m
├── stepwise_fc.m
├── group_analysis.m
├── TFEQ_association.m
└── main_feagures.m

License

📌 copyrightⓒ 2021 All rights reserved by Hyebin Lee