mTADA jointly analyzes de novo mutations (DNMs) of two traits to 1)
estimate the gene-level genetic overlap of the two traits; 2) report
shared and specific risk genes; and 3) identify additional risk genes
for each analyzed trait.
We describe steps to run mTADA in this file: README_mTADA_DD_EE.md or README_mTADA_DD_EE.pdf.
Analysis results of mTADA can be downloaded from https://hoangtn.shinyapps.io/mtadaresults/.
A new version of the package will be updated soon. Please email us, if you plan to use the new version.
This project is licensed under GNU GPL v3.
mTADA is a framework for identifying risk genes from de novo mutations in multiple traits. Tan-Hoang Nguyen, Amanda Dobbyn, Ruth C. Brown, Brien P. Riley, Joseph Buxbaum, Dalila Pinto, Shaun M Purcell, Patrick F
Sullivan, Xin He, Eli A. Stahl.
Nat Commun 11, 2929 (2020). https://doi.org/10.1038/s41467-020-16487-z.