This repo provides the Source code for our TteK paper. The published paper can be viewed and cited:
- Jonsson, A.H.*, Zhang, F.*, Dunlap, G., Gomez-Rivas, E., Watts, G.F.M., Faust, H., Rupani, K., Rupani, K.V., Mears, J.R., Meednu, N., Wang, R., Keras, G., Coblyn J., Massarotti, E., Todd, D., Anolik, J.H., McDavid, A., AMP RA/SLE, Wei, K., Rao, D.A., Raychaudhuri, S.^, Brenner, M.B.^. Granzyme K+ CD8 T cells form a core population in inflamed human tissue, Science Translational Medicine, 2022, Cover article!
*: co-first author
^: co-senior author
The raw and processed data of this study are available at:
- GSE202365 Bulk RNA-seq of human synovial fluid CD8 T cells sorted by Granzyme B vs Granzyme K expression
- GSE202366 Single-cell RNA-seq of CD8 T cells sorted from one sample of seropositive rheumatoid arthritis synovial fluid
- GSE202367 Effect of T cell supernatants or cytokines on synovial fibroblasts
- GSE202375 Pooled single-cell RNA-seq data from T cells from human synovial tissue
Send ajonsson@bwh.harvard.edu and fanzhang@broadinstitute.org (fan.3.zhang@cuanschutz.edu) an email if you have any questions about the data or the analyses.