Merge pull request #664 from isb-cgc/staging

Staging

docs/source/index.rst

@@ -45,6 +45,7 @@ The `ISB-CGC <https://isb-cgc.org>`_ aims to serve the needs of a broad range of
    sections/DataBrowser
    sections/data/Mitelman_about
    sections/the_TP53_database
+   sections/SyntheticLethality_resource
    sections/ProgrammaticAccess
    sections/data/TCGA_Data_Security
    sections/Gaining-Access-To-Controlled-Access-Data 

docs/source/sections/SyntheticLethality_resource.rst

@@ -0,0 +1,28 @@
+***********************
+The Synthetic Lethality Resource
+***********************
+
+Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of
+two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in
+cancer, as exemplified by the recent success of PARP inhibitors in treating BRCA1/2-deficient
+tumors. We present SL-Cloud, a cloud-based integrated resource to facilitate the prediction
+of context-specific SLIs. This resource addresses two main
+challenges related to SLI inference: the need to wrangle and preprocess large multi-omic
+datasets and the multiple comparable prediction approaches available. 
+
+SL-Cloud provides a cloud-based data access platform coupled with software and well documented 
+computational notebooks that reimplement published synthetic lethality (SL) inference algorithms to 
+facilitate novel investigation into synthetic lethality. In addition, we provide general purpose 
+functions that support these prediction workflows, e.g. saving data in BigQuery tables. 
+We anticipate that users can leverage the resources provided in this project 
+to conduct highly customizable analysis based on their cancer type of interest and particular context.
+
+More information about SL-Cloud can be found in the following links:
+
+- `Notebooks in MyBinder <https://mybinder.org/v2/gh/boaguilar/SL-Cloud/HEAD>`_ 
+- `GitHub Repository <https://github.com/IlyaLab/SL-Cloud/>`_ 
+- `Article describing SL-cloud <https://www.biorxiv.org/content/10.1101/2021.09.18.459450v1.abstract>`_
+
+
+
+