na_data.gb

LOCUS       AY331142                2052 bp    mRNA    linear   ROD 22-JUN-2004
DEFINITION  Mus musculus potassium voltage-gated channel major isoform 1
            (Kcnq1) mRNA, complete cds.
ACCESSION   AY331142
VERSION     AY331142.1  GI:33090006
KEYWORDS    .
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Knollmann,B.C., Casimiro,M.C., Katchman,A.N., Sirenko,S.G.,
            Schober,T., Rong,Q., Pfeifer,K. and Ebert,S.N.
  TITLE     Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient
            neonatal mice: possible roles for human-like Kcnq1 isoform 1 and
            slow delayed rectifier K+ current
  JOURNAL   J. Pharmacol. Exp. Ther. 310 (1), 311-318 (2004)
   PUBMED   15004216
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Casimiro,M.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JUN-2003) NICHD, NIH, 9000 Rockville Pike, Bethesda,
            MD 20852, USA
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/SvJ"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /tissue_type="heart"
                     /dev_stage="neonatal"
     gene            1..2052
                     /gene="Kcnq1"
     CDS             21..2027
                     /gene="Kcnq1"
                     /codon_start=1
                     /product="potassium voltage-gated channel major isoform 1"
                     /protein_id="AAP93874.1"
                     /db_xref="GI:33090007"
                     /translation="MDTASSPPSAERKRAGWSRLLGARRGSAVVKKCPFSLELAEGGP
                     EGSTVYAPIAPTGAPGLAPPMSTPVSPAPAPADLGPRPRVSLDPRVSIYSARRPLLAR
                     THIQGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEI
                     VLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKG
                     QVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSS
                     YFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVF
                     AISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSATWK
                     IYVRKPARSHTLLSPSPKPKKSVMVKKKKFKLDKDNGMSPGEKMFNVPHITYDPPEDR
                     RPDHFSIDGYDSSVRKSPTLLELSTPHFLRTNSFAEDLDLEGETLLTPITHVSQLRDH
                     HRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSI
                     GKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSMQQGGPT
                     CNSRSQVVASNEGGSINPELFLPSNSLPTYEQLTVPQTGPDEGS"
ORIGIN      
        1 gtcaggggtc ctgtctggcc atggacacgg cctcgtcccc gcccagtgct gaaaggaagc
       61 gcgcgggttg gagccgcctg ctaggcgccc ggcggggcag cgcggtggtc aagaagtgtc
      121 ccttctcact ggagctggcc gaaggtggcc ctgagggcag cacggtctat gcgcccatcg
      181 cgccaaccgg agcccccggg ctcgcgcccc ccatgtcgac cccagtgtcg cccgccccgg
      241 cccctgcaga cctcggccca cgtccgcggg tgagccttga cccgcgggtc tccatctaca
      301 gtgcgcgccg cccgctgctg gcgcgcaccc acatccaggg ccgagtctac aacttcctcg
      361 agcgccccac gggttggaag tgtttcgtgt accacttcac cgtcttcctc attgttctgg
      421 tctgcctcat cttcagtgtc ctgtccacta ttgagcagta tgccgctctg gccaccggga
      481 ccctcttctg gatggagatt gtccttgtgg tgttctttgg gacagaatat gtggtccgcc
      541 tctggtctgc aggctgccgc agcaagtacg tgggcatctg gggccggcta cgttttgccc
      601 ggaagcccat ttccatcatt gacctcatcg tggttgtagc ctctatggtt gtcctctgcg
      661 tgggttccaa aggacaagtg ttcgccacat cagctatcag gggtatccgc ttccttcaga
      721 tcctgcggat gctgcatgtc gatcgccagg ggggtacctg gaggctcctg ggctctgtag
      781 tcttcattca ccgccaggag ctgatcacca ccctgtacat tggctttctg ggccttatct
      841 tctcctccta ctttgtctac ttggctgaga aagatgcggt gaacgagtcc ggccgcatcg
      901 agtttggcag ctacgcagat gctctgtggt ggggggtggt cacagtcact accattggct
      961 acggggataa ggtacctcag acgtgggttg ggaagaccat cgcctcctgt ttctctgtct
     1021 tcgccatatc cttctttgca ctcccagcgg ggatacttgg ctctgggttc gcgctgaagg
     1081 tccagcagaa gcagaggcag aagcacttca accggcagat cccagctgca gcctcactca
     1141 tccagactgc atggaggtgc tatgccgctg agaaccctga ctcagccact tggaagatct
     1201 atgtccggaa gcctgctcgg agtcacacgc ttctgtcccc cagccccaaa cctaaaaagt
     1261 ctgtcatggt aaagaagaag aagttcaagc tggataagga taatgggatg agtcctggag
     1321 agaagatgtt caatgttcct cacatcactt atgatccccc agaggatagg aggccagacc
     1381 atttctccat tgatggctat gacagctcag taaggaagag ccctacactg ctggaattaa
     1441 gcacacccca tttcttgaga acaaacagct ttgcagagga cctggacctg gaaggggaga
     1501 cactgctgac ccccatcacc catgtgtcac agctgcggga tcaccatcgg gccaccatca
     1561 aggtcatcag gcgcatgcag tactttgtag ccaagaagaa attccagcaa gcacggaagc
     1621 cctacgacgt gcgagatgtc atcgagcagt actcccaggg ccacctgaac cttatggtgc
     1681 gcattaaaga actacagaga aggctggatc agtccattgg gaagccatct ttgttcatcc
     1741 ccatctcaga aaagagcaaa gaccgtggca gtaacaccat cggtgcccgt ctgaacaggg
     1801 tggaagacaa ggtgacacaa ctggaccaga gactggtgat catcacagac atgctccacc
     1861 agctgctgtc catgcaacaa ggtggtccaa cctgcaacag caggtcacaa gttgtagcca
     1921 gcaatgaagg tggctccatc aaccctgagc tcttcctacc cagcaacagc ctgcccacct
     1981 acgaacaact gactgtgccc caaacaggcc ctgatgaggg ttcctgaagg agctcacaag
     2041 ggaggtccag gg
//