This repository contains relevent R code in Jupyter notebooks and serves as a supplement to the following publication:
"Normalized clinical severity scores reveal a correlation between X chromosome inactivation and disease severity in Rett Syndrome"
Any comments or questions should be directed to Jonathan Merritt at jonathan.merritt@vumc.org
xci_datacleaning.ipynb contains the algorithmic process used to correct logical inconsistencies in clinical severity scores pulled from the Natural History of Rett Syndrome & Related Disorders study.
xci_model_build_and_prediction.ipynb contains the various steps used to build, validate, and apply a model of clinical severity.
xci_analysis.ipynb contains analysis of the contribution of X chromosome inactivation to clinical severity using normative severity scores generated using the predictive model above.