SARS-CoV_Signaling_pathway_map.xml

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</celldesigner:protein>
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</celldesigner:protein>
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</celldesigner:protein>
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</celldesigner:protein>
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</celldesigner:listOfModificationResidues>
</celldesigner:protein>
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<celldesigner:protein id="pr138" name="STAT6" type="GENERIC"/>
<celldesigner:protein id="pr139" name="ORF3b" type="GENERIC"/>
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<celldesigner:protein id="pr141" name="ACE2" type="RECEPTOR">
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</celldesigner:protein>
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<celldesigner:protein id="pr146" name="RAF1" type="GENERIC">
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</celldesigner:protein>
<celldesigner:protein id="pr147" name="MAPK2K1" type="GENERIC">
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</celldesigner:protein>
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<celldesigner:RNA id="rn18" name="CXCL8" type="RNA"/>
<celldesigner:RNA id="rn19" name="TNF" type="RNA"/>
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<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfLayers/>
<celldesigner:listOfBlockDiagrams/>
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</annotation>
<listOfUnitDefinitions>
<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00223" kind="mole"/>
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<unit metaid="CDMT00224" kind="litre"/>
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<unit metaid="CDMT00225" kind="metre" exponent="2"/>
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<unitDefinition metaid="length" id="length" name="length">
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<unit metaid="CDMT00226" kind="metre"/>
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</unitDefinition>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00227" kind="second"/>
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<annotation>
<celldesigner:extension>
<celldesigner:name>Plasma Membrane</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c3" id="c3" name="Interferons" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>Interferons</celldesigner:name>
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</annotation>
</compartment>
<compartment metaid="c4" id="c4" name="Cytoplasm" size="1" units="volume" outside="default">
<annotation>
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<celldesigner:name>Cytoplasm</celldesigner:name>
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<compartment metaid="c5" id="c5" name="Nucleus" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>Nucleus</celldesigner:name>
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</annotation>
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<compartment metaid="c6" id="c6" name="SARS-CoV" size="1" units="volume" outside="default">
<annotation>
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<celldesigner:name>SARS-CoV</celldesigner:name>
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</annotation>
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<compartment metaid="c7" id="c7" name="AGONIST" size="1" units="volume" outside="default">
<annotation>
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<celldesigner:name>AGONIST</celldesigner:name>
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<compartment metaid="c8" id="c8" name="Mitochondria" size="1" units="volume" outside="c4">
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<celldesigner:extension>
<celldesigner:name>Mitochondria</celldesigner:name>
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</annotation>
</compartment>
<compartment metaid="c9" id="c9" name="FAS Ligand" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>FAS Ligand</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c10" id="c10" name="Endoplasmic reticulum" size="1" units="volume" outside="c4">
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<celldesigner:extension>
<celldesigner:name>Endoplasmic reticulum</celldesigner:name>
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<species metaid="s148" id="s148" name="IFNG" compartment="c3" initialAmount="0" charge="0">
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IFNG</celldesigner:name>
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<species metaid="s8" id="s8" name="NMI" compartment="c4" initialAmount="0">
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:modification residue="rs1" state="ubiquitinated"/>
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</celldesigner:speciesIdentity>
</celldesigner:extension>
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<species metaid="s11" id="s11" name="ORF6" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr65</celldesigner:proteinReference>
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<celldesigner:catalyzed reaction="re17"/>
<celldesigner:catalyzed reaction="re104"/>
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</annotation>
</species>
<species metaid="s13" id="s13" name="STAT1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr63</celldesigner:proteinReference>
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<celldesigner:homodimer>2</celldesigner:homodimer>
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<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
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</celldesigner:state>
</celldesigner:speciesIdentity>
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<species metaid="s19" id="s19" name="s19" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>DEGRADED</celldesigner:class>
<celldesigner:name>s19</celldesigner:name>
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</annotation>
</species>
<species metaid="s20" id="s20" name="STAT1" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr63</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
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<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re25"/>
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</celldesigner:extension>
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</species>
<species metaid="s33" id="s33" name="ISRE" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ISRE</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s34" id="s34" name="IFIT3" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn8</celldesigner:rnaReference>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s37" id="s37" name="JAK:NMI" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>JAK:NMI</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re15"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s66" id="s66" name="IFNA" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IFNA</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s67" id="s67" name="IFNB" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IFNB</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s68" id="s68" name="IFNE" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IFNE</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s69" id="s69" name="IFNK" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IFNK</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s86" id="s86" name="JAK:TYK2" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>JAK:TYK2</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re23"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s89" id="s89" name="STAT heterodimer" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>STAT heterodimer</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s99" id="s99" name="nsp1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re23"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s223" id="s223" name="IFN induced proteins" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>IFN induced proteins</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s254" id="s254" name="STAT monomers" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>STAT monomers</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s256" id="s256" name="JAK proteins" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>JAK proteins</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s2" id="s2" name="IFNG Receptors" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>IFNG Receptors</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re137"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s273" id="s273" name="STAT monomers" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>STAT monomers</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s275" id="s275" name="JAK proteins" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>JAK proteins</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s281" id="s281" name="IRF9" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr119</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s283" id="s283" name="STAT:IRF9" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>STAT:IRF9</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re26"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s285" id="s285" name="TP53" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr121</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s286" id="s286" name="TP53" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr121</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="ubiquitinated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s288" id="s288" name="s288" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>DEGRADED</celldesigner:class>
<celldesigner:name>s288</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s289" id="s289" name="RCHY:nsp3" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>RCHY:nsp3</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re32"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s290" id="s290" name="Innate immunity" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Innate immunity</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s293" id="s293" name="PLpro:ROS" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>PLpro:ROS</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re37"/>
<celldesigner:catalyzed reaction="re42"/>
<celldesigner:catalyzed reaction="re48"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s294" id="s294" name="MAPK" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr124</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s295" id="s295" name="MAPKAPK2" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr125</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s296" id="s296" name="RP6KA1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr126</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s299" id="s299" name="ATF" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>ATF</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s300" id="s300" name="EIF4E" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr129</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s301" id="s301" name="RAC1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr131</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s303" id="s303" name="HSPB1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr133</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s304" id="s304" name="CREB1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr134</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s305" id="s305" name="ATF2" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr128</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s306" id="s306" name="N" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr135</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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<celldesigner:catalyzed reaction="re47"/>
<celldesigner:catalyzed reaction="re63"/>
<celldesigner:catalyzed reaction="re77"/>
<celldesigner:catalyzed reaction="re98"/>
<celldesigner:catalyzed reaction="re102"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s308" id="s308" name="CUZD1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr137</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s309" id="s309" name="CUZD1" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr137</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s312" id="s312" name="TGFB1:TGBS1" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>TGFB1:TGBS1</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s313" id="s313" name="STAT6" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr138</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s315" id="s315" name="CUZD1" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn11</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s316" id="s316" name="ORF3b" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr139</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re53"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s317" id="s317" name="S" compartment="c6" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr140</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s320" id="s320" name="ACE2:S" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>ACE2:S</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s321" id="s321" name="TMPRSS2" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr142</celldesigner:proteinReference>
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<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s326" id="s326" name="CSNK2A1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re57"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s327" id="s327" name="RAS" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr145</celldesigner:proteinReference>
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<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s328" id="s328" name="RAF1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr146</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s331" id="s331" name="MAPK2K" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAPK2K</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s334" id="s334" name="MAPK" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAPK</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s351" id="s351" name="AP1" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>AP1</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s355" id="s355" name="CCL2" compartment="c5" initialAmount="0">
<annotation>
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<annotation>
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<annotation>
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<annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
</species>
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</annotation>
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</annotation>
</species>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
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</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAPK2K</celldesigner:name>
</celldesigner:speciesIdentity>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s492" id="s492" name="MAPK" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAPK</celldesigner:name>
</celldesigner:speciesIdentity>
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<celldesigner:catalyzed reaction="re63"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s496" id="s496" name="AP1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>AP1</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s500" id="s500" name="AP1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>AP1</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr157</celldesigner:proteinReference>
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</celldesigner:state>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s505" id="s505" name="NFKB" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>NFKB</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr177</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s513" id="s513" name="MAVS" compartment="c8" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re116"/>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s514" id="s514" name="DDX58" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr166</celldesigner:proteinReference>
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<celldesigner:listOfModifications>
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</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re115"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s515" id="s515" name="STING1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr170</celldesigner:proteinReference>
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</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re81"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s417" id="s417" name="CYS" compartment="c8" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr181</celldesigner:proteinReference>
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<celldesigner:catalyzed reaction="re96"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr177</celldesigner:proteinReference>
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<celldesigner:homodimer>2</celldesigner:homodimer>
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<celldesigner:modification residue="rs1" state="ubiquitinated"/>
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</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re87"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>FAS-L</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>ACE2:S</celldesigner:name>
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<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re58"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s523" id="s523" name="MAPK2K" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAPK2K</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re37"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s526" id="s526" name="PI3K" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>PI3K</celldesigner:name>
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<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re117"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr199</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s528" id="s528" name="AKT1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr199</celldesigner:proteinReference>
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<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re119"/>
<celldesigner:catalyzed reaction="re131"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s530" id="s530" name="GSK3B" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr200</celldesigner:proteinReference>
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<celldesigner:modification residue="rs1" state="phosphorylated"/>
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</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s534" id="s534" name="PRKC" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>PRKC</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s535" id="s535" name="M" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr204</celldesigner:proteinReference>
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</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>IKK complex</celldesigner:name>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s540" id="s540" name="PYCARD" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr175</celldesigner:proteinReference>
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</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re83"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s541" id="s541" name="NFKB" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>NFKB</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s544" id="s544" name="TRAF-TBK-IKK" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>TRAF-TBK-IKK</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re82"/>
<celldesigner:catalyzed reaction="re84"/>
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</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr177</celldesigner:proteinReference>
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</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s413" id="s413" name="DNM1L" compartment="c8" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>outerSurface</celldesigner:positionToCompartment>
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<celldesigner:class>PROTEIN</celldesigner:class>
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</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr206</celldesigner:proteinReference>
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</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species metaid="s555" id="s555" name="Ca2+" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Apoptosis</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s302" id="s302" name="STAT3" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s483" id="s483" name="STAT3" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s562" id="s562" name="Pulmonary Pro-fibrosis" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Pulmonary Pro-fibrosis</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s563" id="s563" name="Development of lung fibrosis" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Development of lung fibrosis</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s564" id="s564" name="Persistence of infection" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Persistence of infection</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s565" id="s565" name="GSK3B" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr200</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s566" id="s566" name="PRKC" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>PRKC</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s572" id="s572" name="MAP2K" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAP2K</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re133"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s573" id="s573" name="MAP2K" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAP2K</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s578" id="s578" name="MAPK" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAPK</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s585" id="s585" name="MAPK" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>MAPK</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s589" id="s589" name="IFN" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>IFN</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s590" id="s590" name="ORF8b" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr213</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re84"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s591" id="s591" name="ORF8ab" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr214</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re84"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s592" id="s592" name="Inhibition of Type 1 IFN activation" compartment="c5" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Inhibition of Type 1 IFN activation</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s594" id="s594" name="ORF3a" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr216</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re81"/>
<celldesigner:catalyzed reaction="re91"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s595" id="s595" name="Apoptosis" compartment="c10" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Apoptosis</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s608" id="s608" name="IFNA Receptors" compartment="c2" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>IFNA Receptors</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re22"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s613" id="s613" name="HSPB1" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr133</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s621" id="s621" name="CASP8" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr183</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re93"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s622" id="s622" name="ITCH" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr168</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re115"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s632" id="s632" name="Agonist" compartment="c7" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Agonist</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re12" id="re12" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="csa2">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="csa1">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00025" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00026" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re15" id="re15" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s273" alias="csa3">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s13" alias="sa23">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s47" aliases="sa20" targetLineIndex="-1,2" editPoints="0.3086991162385093,-0.4619566774840127">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s47" alias="sa20">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00031" species="s273">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00032" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00001" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re17" id="re17" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa23">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s20" alias="sa29">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s11" aliases="sa21" targetLineIndex="-1,6" editPoints="0.09604005958635442,0.29379074383465054">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s11" alias="sa21">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00037" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00038" species="s20">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00229" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re21" id="re21" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s608" alias="csa12">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s608" alias="csa14">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00049" species="s608">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00050" species="s608">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re22" id="re22" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s256" alias="csa13">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s86" alias="csa15">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s608" aliases="csa14" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s608" alias="csa14">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00051" species="s256">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00052" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00053" species="s608">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re23" id="re23" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s254" alias="csa16">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s89" alias="csa17">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s99" aliases="sa73" targetLineIndex="-1,6">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s99" alias="sa73">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s86" aliases="csa15" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s86" alias="csa15">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00054" species="s254">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00055" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00230" species="s99">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa73</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00231" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa15</celldesigner:alias>
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</annotation>
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</reaction>
<reaction metaid="re25" id="re25" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa35</celldesigner:alias>
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</annotation>
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</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00003" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa36</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00004" species="s20">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:baseProducts>
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<speciesReference metaid="CDMT00005" species="s33">
<annotation>
<celldesigner:extension>
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<listOfProducts>
<speciesReference metaid="CDMT00006" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa36</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00007" species="s283">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa18</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff6699ff"/>
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</annotation>
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<speciesReference metaid="CDMT00008" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa36</celldesigner:alias>
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<listOfProducts>
<speciesReference metaid="CDMT00009" species="s223">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa19</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</annotation>
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<speciesReference metaid="CDMT00010" species="s89">
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<celldesigner:extension>
<celldesigner:alias>csa17</celldesigner:alias>
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<speciesReference metaid="CDMT00011" species="s281">
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<celldesigner:alias>sa88</celldesigner:alias>
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</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00012" species="s283">
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<celldesigner:extension>
<celldesigner:alias>csa18</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00013" species="s285">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa94</celldesigner:alias>
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</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00014" species="s286">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa95</celldesigner:alias>
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</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00015" species="s289">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa23</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<celldesigner:extension>
<celldesigner:reactionType>PHYSICAL_STIMULATION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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<celldesigner:extension>
<celldesigner:alias>sa98</celldesigner:alias>
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<celldesigner:extension>
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<celldesigner:extension>
<celldesigner:alias>sa98</celldesigner:alias>
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<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00045" species="s299">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00046" species="s478">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa26</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00034" species="s475">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa102</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re41" id="re41" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>UNKNOWN_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s300" alias="sa111">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s482" alias="sa112">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s475" alias="sa102">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00058" species="s300">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa111</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00059" species="s482">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa112</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00035" species="s475">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa102</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re42" id="re42" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s301" alias="sa113">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s560" alias="sa114">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s293" aliases="csa24" targetLineIndex="-1,2" editPoints="0.9525581377265322,-0.21258205939708308">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s293" alias="csa24">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00061" species="s301">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa113</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00062" species="s560">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa114</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00234" species="s293">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa24</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re43" id="re43" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s483" alias="sa115">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s302" alias="sa116">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s475" aliases="sa102" targetLineIndex="-1,2" editPoints="0.9695741916133915,-0.17175586910095827">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s475" alias="sa102">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00064" species="s483">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa115</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00065" species="s302">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa116</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00066" species="s475">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa102</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re44" id="re44" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>UNKNOWN_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s303" alias="sa117">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s613" alias="sa118">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s476" aliases="sa104" targetLineIndex="-1,2">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s476" alias="sa104">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00067" species="s303">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa117</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00068" species="s613">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa118</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00036" species="s476">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa104</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re45" id="re45" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>UNKNOWN_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s481" alias="sa120">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s477" aliases="sa106" targetLineIndex="-1,2">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s477" alias="sa106">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00070" species="s304">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa119</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00071" species="s481">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa120</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00236" species="s477">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa106</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re46" id="re46" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>UNKNOWN_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s305" alias="sa125">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00073" species="s478">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa26</celldesigner:alias>
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<listOfProducts>
<speciesReference metaid="CDMT00074" species="s305">
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00075" species="s306">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa126</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:linkTarget species="s306" alias="sa126">
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<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00076" species="s481">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa120</celldesigner:alias>
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</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00077" species="s481">
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<celldesigner:extension>
<celldesigner:alias>sa128</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00078" species="s306">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa126</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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<speciesReference metaid="CDMT00079" species="s308">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa129</celldesigner:alias>
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</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00080" species="s308">
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<celldesigner:extension>
<celldesigner:alias>sa130</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00081" species="s293">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa24</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re50" id="re50" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s312" alias="csa29">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00084" species="s309">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa131</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00085" species="s312">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa29</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re53" id="re53" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:baseReactant species="s302" alias="sa116">
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s314" alias="sa135">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:listOfLineDirection>
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:modification type="INHIBITION" modifiers="s316" aliases="sa137" targetLineIndex="-1,6">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s316" alias="sa137">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00088" species="s302">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa116</celldesigner:alias>
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</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00089" species="s314">
<annotation>
<celldesigner:extension>
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<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00090" species="s316">
<annotation>
<celldesigner:extension>
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</annotation>
</modifierSpeciesReference>
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</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00091" species="s314">
<annotation>
<celldesigner:extension>
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<listOfProducts>
<speciesReference metaid="CDMT00092" species="s315">
<annotation>
<celldesigner:extension>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re55" id="re55" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
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</annotation>
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<annotation>
<celldesigner:extension>
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</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00094" species="s308">
<annotation>
<celldesigner:extension>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re56" id="re56" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseProducts>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00095" species="s317">
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<listOfProducts>
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</listOfProducts>
<listOfModifiers>
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<annotation>
<celldesigner:extension>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00099" species="s320">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa30</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00100" species="s518">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa31</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00101" species="s326">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa145</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re58" id="re58" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseProducts>
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<celldesigner:line width="2.0" color="ff000000"/>
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<listOfProducts>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00104" species="s518">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa31</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:modification>
</celldesigner:listOfModification>
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</annotation>
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<annotation>
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</speciesReference>
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<listOfProducts>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00238" species="s306">
<annotation>
<celldesigner:extension>
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</annotation>
</modifierSpeciesReference>
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</annotation>
<listOfReactants>
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</listOfProducts>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
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</speciesReference>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseProducts>
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
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</speciesReference>
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</speciesReference>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</annotation>
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<celldesigner:extension>
<celldesigner:alias>sa176</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00125" species="s504">
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<celldesigner:extension>
<celldesigner:alias>sa177</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
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<annotation>
<celldesigner:extension>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00082" species="s461">
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<celldesigner:extension>
<celldesigner:alias>sa175</celldesigner:alias>
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</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00240" species="s359">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa178</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00241" species="s359">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa179</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00242" species="s504">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa177</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re70" id="re70" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:baseReactant species="s363" alias="csa41">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s359" aliases="sa179" targetLineIndex="-1,2">
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s359" alias="sa179">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00131" species="s363">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00132" species="s536">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00133" species="s359">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa179</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re71" id="re71" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s364" alias="sa186">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s364" alias="sa187">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s536" aliases="csa40" targetLineIndex="-1,2">
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<celldesigner:linkTarget species="s536" alias="csa40">
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<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00134" species="s364">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa186</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00135" species="s364">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa187</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00136" species="s536">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re72" id="re72" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s541" alias="csa43">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s364" aliases="sa187" targetLineIndex="-1,2">
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s364" alias="sa187">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00243" species="s505">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa42</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00244" species="s541">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00245" species="s364">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa187</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re73" id="re73" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s541" alias="csa43">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s371" alias="csa44">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s380" alias="sa270">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00246" species="s541">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00247" species="s371">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00248" species="s380">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa270</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re74" id="re74" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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<celldesigner:baseReactant species="s371" alias="csa44">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s589" alias="csa45">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s379" alias="sa198">
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00143" species="s371">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00144" species="s589">
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<celldesigner:extension>
<celldesigner:alias>csa45</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00145" species="s379">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa198</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re77" id="re77" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:baseReactant species="s390" alias="sa205">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s514" alias="sa206">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s306" alias="sa211">
<celldesigner:linkAnchor position="SSE"/>
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s389" aliases="sa204" targetLineIndex="-1,5">
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s389" alias="sa204">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<speciesReference metaid="CDMT00150" species="s390">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa205</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00151" species="s514">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa206</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00153" species="s306">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa211</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00040" species="s389">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa204</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re79" id="re79" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s622" alias="sa209">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00160" species="s622">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa210</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00161" species="s622">
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<celldesigner:extension>
<celldesigner:alias>sa209</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s544" alias="csa48">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:linkTarget species="s515" alias="sa213">
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<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s594" aliases="sa314" targetLineIndex="-1,7" editPoints="0.41201808609233126,-0.4899758816014419">
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<celldesigner:linkTarget species="s594" alias="sa314">
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<celldesigner:modification type="INHIBITION" modifiers="s535" aliases="sa312" targetLineIndex="-1,6" editPoints="0.2753063784396197,0.2827262882725279 0.4952624658535463,0.504787420067867">
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<celldesigner:linkTarget species="s535" alias="sa312">
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<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00166" species="s470">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00167" species="s544">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00249" species="s515">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa213</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00251" species="s594">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa314</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00041" species="s535">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa312</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re82" id="re82" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s540" alias="sa224">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
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</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s544" aliases="csa48" targetLineIndex="-1,2">
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<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s544" alias="csa48">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00169" species="s405">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa223</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00170" species="s540">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa224</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00252" species="s544">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re83" id="re83" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s406" alias="sa226">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s540" aliases="sa224" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s540" alias="sa224">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s364" aliases="sa187" targetLineIndex="-1,4" editPoints="0.9206182947244628,-0.2704045318352062">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s364" alias="sa187">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00172" species="s406">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa225</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00173" species="s406">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa226</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00174" species="s540">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa224</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00175" species="s364">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa187</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re84" id="re84" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s550" alias="sa228">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
<celldesigner:listOfModification>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s591" alias="sa310">
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</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s544" aliases="csa48" targetLineIndex="-1,4">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s544" alias="csa48">
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:modification type="INHIBITION" modifiers="s590" aliases="sa309" targetLineIndex="-1,5" editPoints="0.7512300290676919,0.43664458975962717">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s590" alias="sa309">
<celldesigner:linkAnchor position="W"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00176" species="s511">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa227</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00177" species="s550">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa228</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00254" species="s591">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa310</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00042" species="s544">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00044" species="s590">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa309</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re85" id="re85" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s408" alias="sa229">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00179" species="s550">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa228</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00180" species="s408">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa229</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re86" id="re86" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00181" species="s550">
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<celldesigner:extension>
<celldesigner:alias>sa228</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00182" species="s409">
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<celldesigner:extension>
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</annotation>
</speciesReference>
</listOfProducts>
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<reaction metaid="re87" id="re87" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<celldesigner:extension>
<celldesigner:alias>sa231</celldesigner:alias>
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</annotation>
</speciesReference>
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</annotation>
</speciesReference>
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<celldesigner:extension>
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</modifierSpeciesReference>
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</annotation>
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<celldesigner:extension>
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</speciesReference>
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</annotation>
</speciesReference>
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<celldesigner:extension>
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProducts>
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</annotation>
<listOfReactants>
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<celldesigner:extension>
<celldesigner:alias>sa237</celldesigner:alias>
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</speciesReference>
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<celldesigner:extension>
<celldesigner:alias>sa235</celldesigner:alias>
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseProducts>
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<celldesigner:linkTarget species="s594" alias="sa263">
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<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s422" aliases="sa240" targetLineIndex="-1,2">
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</annotation>
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<speciesReference metaid="CDMT00191" species="s621">
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<celldesigner:extension>
<celldesigner:alias>sa241</celldesigner:alias>
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</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00192" species="s621">
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<celldesigner:extension>
<celldesigner:alias>sa242</celldesigner:alias>
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<celldesigner:extension>
<celldesigner:alias>sa263</celldesigner:alias>
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</modifierSpeciesReference>
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<celldesigner:extension>
<celldesigner:alias>sa240</celldesigner:alias>
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</modifierSpeciesReference>
</listOfModifiers>
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkTarget species="s426" alias="sa245">
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s621" alias="sa242">
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<celldesigner:modification type="CATALYSIS" modifiers="s442" aliases="sa264" targetLineIndex="-1,2">
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</celldesigner:connectScheme>
<celldesigner:linkTarget species="s442" alias="sa264">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="2.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00194" species="s425">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa244</celldesigner:alias>
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</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00195" species="s425">
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<celldesigner:extension>
<celldesigner:alias>sa243</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00196" species="s426">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa245</celldesigner:alias>
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<annotation>
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<annotation>
<celldesigner:extension>
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</annotation>
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<annotation>
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</annotation>
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<modifierSpeciesReference metaid="CDMT00201" species="s429">
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<annotation>
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</annotation>
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<annotation>
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</annotation>
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</annotation>
</speciesReference>
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</annotation>
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</modifierSpeciesReference>
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<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</speciesReference>
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</reaction>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00265" species="s288">
<annotation>
<celldesigner:extension>
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</annotation>
</speciesReference>
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</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</annotation>
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<annotation>
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</annotation>
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</listOfReactants>
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<annotation>
<celldesigner:extension>
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</annotation>
</speciesReference>
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</reaction>
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<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:listOfModification>
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</annotation>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00269" species="s484">
<annotation>
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<celldesigner:alias>sa149</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00270" species="s327">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa147</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re110" id="re110" reversible="false">
<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
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<celldesigner:line width="2.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00271" species="s331">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00272" species="s485">
<annotation>
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<celldesigner:alias>csa33</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
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</celldesigner:extension>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00275" species="s492">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
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<listOfModifiers>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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</listOfReactants>
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</annotation>
</speciesReference>
</listOfProducts>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
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</annotation>
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</annotation>
</speciesReference>
</listOfReactants>
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</annotation>
</speciesReference>
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</annotation>
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</annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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</celldesigner:baseProducts>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00289" species="s515">
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00290" species="s513">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa208</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00291" species="s380">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa199</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>UNKNOWN_TRANSITION</celldesigner:reactionType>
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</annotation>
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<annotation>
<celldesigner:extension>
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<celldesigner:extension>
<celldesigner:alias>csa60</celldesigner:alias>
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<speciesReference metaid="CDMT00329" species="s585">
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<celldesigner:alias>csa61</celldesigner:alias>
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</annotation>
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<modifierSpeciesReference metaid="CDMT00330" species="s572">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa59</celldesigner:alias>
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</modifierSpeciesReference>
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</reaction>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s592" alias="sa311">
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</celldesigner:baseProducts>
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00331" species="s410">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa232</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00332" species="s592">
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<celldesigner:extension>
<celldesigner:alias>sa311</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re136" id="re136" reversible="false">
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s561" alias="sa316">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00335" species="s425">
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<celldesigner:extension>
<celldesigner:alias>sa243</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00336" species="s561">
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<celldesigner:extension>
<celldesigner:alias>sa316</celldesigner:alias>
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</annotation>
</speciesReference>
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</reaction>
<reaction metaid="re137" id="re137" reversible="false">
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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<celldesigner:line width="2.0" color="ff000000"/>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>csa6</celldesigner:alias>
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</annotation>
</speciesReference>
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<listOfProducts>
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<celldesigner:extension>
<celldesigner:alias>csa4</celldesigner:alias>
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</annotation>
</speciesReference>
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<modifierSpeciesReference metaid="CDMT00057" species="s2">
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<celldesigner:extension>
<celldesigner:alias>csa1</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
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</reaction>
<reaction metaid="re138" id="re138" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>PHYSICAL_STIMULATION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s595" alias="sa315">
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</celldesigner:baseProducts>
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<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00060" species="s553">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa288</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00063" species="s595">
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<celldesigner:extension>
<celldesigner:alias>sa315</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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</reaction>
<reaction metaid="re139" id="re139" reversible="false">
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<celldesigner:extension>
<celldesigner:reactionType>PHYSICAL_STIMULATION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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<celldesigner:connectScheme connectPolicy="direct">
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</celldesigner:connectScheme>
<celldesigner:line width="2.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00069" species="s293">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa24</celldesigner:alias>
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</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00072" species="s561">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa296</celldesigner:alias>
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</annotation>
</speciesReference>
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</reaction>
</listOfReactions>
</model>
</sbml>