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repository for analyses in paper "Analysis of regulatory element evolution between human and mouse reveals a lack of cis-trans compensation"

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Cis and trans effects differentially contribute to the evolution of promoters and enhancers

This repository contains all of the MPRA analysis performed in this paper. Each is done in a Jupyter notebook, which contains its own description of what was done to create files/figures.

Most of the code in this repository runs on Python 3 and requires the following packages:

  • matplotlib
  • numpy
  • pandas
  • seaborn
  • statsmodels
  • scikit-learn

MPRA analysis runs in R and requires the MPRAnalyze package. RNA-seq analysis also runs in R and requires the DESeq2 and edgeR/limma packages.

This software is open source under the MIT License.

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repository for analyses in paper "Analysis of regulatory element evolution between human and mouse reveals a lack of cis-trans compensation"

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