coxKM (cox Kernel Machine)

coxKM (cox Kernel Machine) is an R package for conducting SNP-set association tests for right-censored survival outcomes based on a kernel machine cox regression framework. coxKM is meant for common genetic variants only. coxKM tests for association between a SNP-set (made up of common variants) and a right-censored survival outcome.

Manual

You can download the manual here.

References:

• Lin X, Cai T, Wu M, Zhou Q, Liu G, Christiani D and Lin X. 2011. Survival Kernel Machine SNP-set Analysis for Genome-wide Association Studies. Genetic Epidemiology 35:620-31. doi:10.1002/gepi.20610
• Cai T, Tonini G and Lin X. 2011. Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics, 67:975-86. doi:10.1111/j.1541-0420.2010.01544.x