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Advanced Femtosecond Spectroscopy Techniques
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<p>Exploring electron and energy transfer in inorganic functional materials and protein systems</p>
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<h1 class="title">Novel Porphyrin Molecules for Energy and Imaging Applications</h1>
<h1 class="title">Advanced Femtosecond Spectroscopy Techniques</h1>
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Synthesis of semiconducting nanowires, formulating nanowire inks, and creating various printed electronic devices using these inks
Exploring electron and energy transfer in inorganic functional materials and protein systems
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<h2 id="toc-title">On this page</h2>

<ul>
<li><a href="#ultrafast-laser-spectroscopy" id="toc-ultrafast-laser-spectroscopy" class="nav-link active" data-scroll-target="#ultrafast-laser-spectroscopy">Ultrafast Laser Spectroscopy</a></li>
<li><a href="#maintaining-and-improving-the-femtosecond-laser-spectrometer" id="toc-maintaining-and-improving-the-femtosecond-laser-spectrometer" class="nav-link active" data-scroll-target="#maintaining-and-improving-the-femtosecond-laser-spectrometer">Maintaining and Improving the Femtosecond Laser Spectrometer</a></li>
<li><a href="#ultrafast-pump-probe-spectroscopy" id="toc-ultrafast-pump-probe-spectroscopy" class="nav-link" data-scroll-target="#ultrafast-pump-probe-spectroscopy">Ultrafast Pump-Probe Spectroscopy</a></li>
<li><a href="#femtosecond-2d-ir-spectroscopy" id="toc-femtosecond-2d-ir-spectroscopy" class="nav-link" data-scroll-target="#femtosecond-2d-ir-spectroscopy">Femtosecond 2D-IR Spectroscopy</a></li>
<li><a href="#selected-publications" id="toc-selected-publications" class="nav-link" data-scroll-target="#selected-publications">Selected Publications</a></li>
<li><a href="#selected-posters-and-presentations" id="toc-selected-posters-and-presentations" class="nav-link" data-scroll-target="#selected-posters-and-presentations">Selected Posters and Presentations</a></li>
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<section id="ultrafast-laser-spectroscopy" class="level2">
<h2 class="anchored" data-anchor-id="ultrafast-laser-spectroscopy">Ultrafast Laser Spectroscopy</h2>
<p>The Therien Group at the University of Pennsylvania (now at <a href="https://sites.duke.edu/therienlab/research/">Duke University</a>)</p>
<p>I had a joint post-doctoral appointment with the late Prof.&nbsp;Robin Hochstrasser and Prof.&nbsp;Michael Therien at the University of Pennsylvania, where I researched the role of the environment on electron and energy transfer processes. Prof.&nbsp;Therien, now at&nbsp;<a href="https://sites.duke.edu/therienlab/research/">Duke University</a>, is a leading expert on functional materials for energy and photonic applications. His lab produced various exciting materials that I was lucky enough to study. Prof.&nbsp;Hochstrasser developed cutting-edge spectroscopic techniques, and I could perform multiple femtosecond spectroscopies in his laser lab.</p>
<section id="maintaining-and-improving-the-femtosecond-laser-spectrometer" class="level2 page-columns page-full">
<h2 class="anchored" data-anchor-id="maintaining-and-improving-the-femtosecond-laser-spectrometer">Maintaining and Improving the Femtosecond Laser Spectrometer</h2>
<p>The femtosecond spectroscopy system was a complicated instrument designed to perform a variety of experiments for both labs: visible pump-probe, infrared pump-probe, and two-dimensional infrared (2DIR) spectroscopies. I continually improved the system throughout my post-doc. I improved the pump-probe experiment by reducing the temporal chirp 5-fold by redesigning the supercontinuum generation module and compensating for the spatial chirp by adjusting the relative size of the pump and probe beams. Upgrades to the optical train for the infrared beam path improved the power of the pump and probe beam.</p>

<div class="no-row-height column-margin column-container"><div class="">
<p><img src="OPAs.jpg" class="img-fluid" alt="a small portion of the laser table with dozens of different mirrors and crystals."></p>
</div></div></section>
<section id="ultrafast-pump-probe-spectroscopy" class="level2 page-columns page-full">
<h2 class="anchored" data-anchor-id="ultrafast-pump-probe-spectroscopy">Ultrafast Pump-Probe Spectroscopy</h2>
<p>Most of my spectroscopic work was performing visible pump and visible or near IR probe spectroscopy on the novel materials produced by the Therien Group. Since the materials were generated for various applications and with a range of physical properties, many different models were employed to analyze the data. Most fitting was performed with OriginPro, some with the built-in fitting, but some with custom functions I wrote using the built-in scripting language. The sheer variety of projects I got to participate in was a joy.</p>

<div class="no-row-height column-margin column-container"><div class="">
<p><img src="meijer_model.jpg" class="img-fluid" alt="a graph with points and a fit showing exponential rise to a plateau. the x axis is the number of double bonds in the molecule and the y axis is the wavelength of emission"></p>
</div></div></section>
<section id="femtosecond-2d-ir-spectroscopy" class="level2 page-columns page-full">
<h2 class="anchored" data-anchor-id="femtosecond-2d-ir-spectroscopy">Femtosecond 2D-IR Spectroscopy</h2>
<p>Ultrafast infrared spectroscopy is the most challenging spectroscopic technique I have ever performed. Not only are all the beams invisible, making alignment of the system a massive challenge, but ambient atmospheric components, such as humidity, strongly absorb most beams.</p>

<div class="no-row-height column-margin column-container"><div class="">
<p><img src="formamide.jpg" class="img-fluid" alt="a multicolor contour graph showing the interaction between the vibrational modes at 1680 and 2160 wavenumbers"></p>
</div></div><p>My main research focus was understanding non-traditional hydrogen bonds. These hydrogen bonds are postulated to be critically important for forming and stabilizing complicated protein structures. While these hydrogen bonds are much weaker than conventional ones, a protein structure can have dozens of them, leading to substantial stability of the folded protein. I studied these hydrogen bonds with my colleague Dr.&nbsp;Kumar in a simple model system based on the molecule formamide. Later, I worked on hydrogen bonding within the structure of the trans-membrane protein gylcophorin A.</p>
</section>
<section id="selected-publications" class="level2">
<h2 class="anchored" data-anchor-id="selected-publications">Selected Publications</h2>
<p>Park, J.; Park, T.-H.; <strong>Sinks, L. E.</strong>; Deria, P.; Park, J.; Baik, M.-H.; Therien, M. J. <a href="https://pubs.rsc.org/en/content/articlehtml/2018/me/c8me00001h">Unusual Solvent Polarity Dependent Excitation Relaxation Dynamics of a Bis [p-Ethynyldithiobenzoato] Pd-Linked Bis [(Porphinato) Zinc] Complex</a>. <em>Molecular Systems Design &amp; Engineering</em> <strong>2018</strong>, <em>3</em> (1), 275–284.</p>
<p>Fry, H. C.; Lehmann, A.; <strong>Sinks, L. E.</strong>; Asselberghs, I.; Tronin, A.; Krishnan, V.; Blasie, J. K.; Clays, K.; DeGrado, W. F.; Saven, J. G.; Therien, M. J. <a href="https://pubs.acs.org/doi/abs/10.1021/ja4067404">Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore</a>. J. Am. Chem. Soc. <strong>2013</strong>, 135, 13914–26.</p>
<p>Ishizuka, T.; <strong>Sinks, L. E.</strong>; Song, K.; Hung, S.-T.; Nayak, A.; Clays, K.; Therien, M. J. <a href="https://pubs.acs.org/doi/abs/10.1021/ja105004k">The roles of molecular structure and effective optical symmetry in evolving dipolar chromophoric building blocks to potent octopolar nonlinear optical chromophores</a>. J. Am. Chem. Soc. <strong>2010</strong>, 133, 2884–2896.</p>
<p>Deria, Pravas; <strong>Sinks, Louise</strong>; Park, Tae-Hong; Tomezsko, Diana; Brukman, Matthew; Bonnell, Dawn; Therien, Michael, <a href="https://pubs.acs.org/doi/abs/10.1021/nl102540c">Phase Transfer Catalysts Drive Diverse Organic Solvent Solubility of Single-Walled Carbon Nanotubes Helically Wrapped by Ionic, Semi-Conducting Polymers</a>. Nano Letters, <strong>2010</strong>, 10(10), 4192-4199.</p>
<p>Kumar, K.; <strong>Sinks, L. E</strong>.; Wang, J.; Kim, Y. S.; Hochstrasser, R. M., <a href="https://www.sciencedirect.com/science/article/abs/pii/S0009261406015284">Coupling between C-D and CO motions using dual-frequency two-dimensional IR photon echo spectroscopy</a>. Chem. Phys. Lett. 2006, 432 (1-3), 122-27.</p>
<p>Duncan, T. V.; Susumu, K.; <strong>Sinks, L. E.</strong>; Therien, M. J., <a href="https://pubs.acs.org/doi/abs/10.1021/ja061897o">Exceptional Near-Infrared Fluorescence Quantum Yields and Excited-State Absorptivity of Highly Conjugated Porphyrin Arrays</a>. J. Am. Chem. Soc. <strong>2006</strong>, 128 (28), 9000-01.</p>
</section>
<section id="selected-posters-and-presentations" class="level2">
<h2 class="anchored" data-anchor-id="selected-posters-and-presentations">Selected Posters and Presentations</h2>
<p>Sinks, L. E.; Frail, P. R.; Therien, M. J. SYMPOSIUM LECTURES-Photophysics of Porphyrins in Solution and in Films. <em>Journal of Porphyrins and Phthalocyanines</em> <strong>2006</strong>, <em>10</em> (4–6), 399–399 presented at the International Conference on Porphyrins and Phthalocyanines Rome, Italy July 2006</p>
<iframe width="780" height="500" src="Sinks_ICPP4B.pdf" title="Microscopy Presentation"></iframe>
<p>“Visible Pump/ IR Probe Technique”, 1st Annual Ultrafast Spectroscopy Workshop Sarasota, FL January 2010</p>


</section>
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