So easy! Python just import sqlite3 and the db file is crackmes.db. Optionally grab http://crackmesus.dreamhosters.com/crackmes.db to get started.
Note that wrapdb.py is the only thing that imports this because, all database requests are supposed to funnel thru this module so that there's a central place to sanitize input.
Not in the repo, but create directory ./attachments and seed it with http://crackmesus.dreamhosters.com/attachments.
I test during development with thttpd, invoking it with thttpd -p 8080 -c "*.py" -D and navigating my browser to http://localhost:8080/index.py.
Any other server just needs to be configured to execution python. For servers support .htaccess style directives (apache, nginx), I use:
DirectoryIndex index.py
Options +ExecCGI
AddHandler cgi-script .py
AddHandler cgi-script .cgi