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A new method called A-D test was developed to Genome-wide association studies (GWAS). One open R package [including manual and sample data] could be used easily to make the A-D test for GWAS.
Related papers:
Yang et al. Genome Wide Association Studies Using a New Nonparametric Model Reveal the Genetic Architecture of 17 Agronomic Traits in an Enlarged Maize Association Panel. PLoS Genet. 2014; 10(9):e1004573. doi: 10.1371/journal.pgen.1004573.