The easiest way to run this software is to install pipenv to manage packets and environemnts. If you don't believe in pipenv, you can install packages mentioned in Pipfile.
If you have installed pipenv, clone the repo and:
$ cd pytooth
$ make build_env
$ make run
If you don't have pipenv, install packages and evaluate python3 run.py.
If you want to change network configuration, you can do that in run.py file.