This repository provides the sorafenib physiologically based pharmacokinetics (PBPK) model.
The model is distributed as SBML available from sorafenib_body_flat.xml with
corresponding SBML4humans model report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/sorafenib-model/main/models/sorafenib_body_flat.xml and equations from sorafenib_body_flat.md.
The liver submodel is available from sorafenib_liver.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/sorafenib-model/main/models/sorafenib_liver.xml and equations from sorafenib_liver.md.
The kidney submodel is available from sorafenib_kidney.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/sorafenib-model/main/models/sorafenib_kidney.xml and equations from sorafenib_kidney.md.
The intestine submodel is available from sorafenib_intestine.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/sorafenib-model/main/models/sorafenib_intestine.xml and equations from sorafenib_intestine.md.
The whole-body submodel is available from sorafenib_body.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/sorafenib-model/main/models/sorafenib_body.xml and equations from sorafenib_body.md.
Okibedi Frances, & König, Matthias. (2023). Physiologically based pharmacokinetic (PBPK) model of sorafenib.
Zenodo. https://doi.org/10.5281/zenodo.10432855
- Source Code: LGPLv3
- Documentation: CC BY-SA 4.0
- Models: CC BY-SA 4.0
The sorafenib-model source is released under both the GPL and LGPL licenses version 2 or later. You may choose which license you choose to use the software under.
This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License or the GNU Lesser General Public License as published by the Free Software Foundation, either version 2 of the License, or (at your option) any later version.
This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.
Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).
© 2021-2023 Frances Okibedi & Matthias König, Systems Medicine of the Liver